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PMID: 7565730 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family.

Molecular and cellular biology ·Vol. 15 ·No. 10 ·1995-10-00 ·Pages 5770-6

Riese DJ, van Raaij TM, Plowman GD, Andrews GC, Stern DF

Abstract

Deregulated signaling by the four members of the epidermal growth factor receptor tyrosine kinase family (erbB family) is implicated in the genesis or progression of human cancers. However, efforts to analyze signaling by these receptors have been hampered by the diversity of ligands and extensive interreceptor cross talk. We have expressed the four human erbB family receptors, singly and in pairwise combinations, in a pro-B-lymphocyte cell line (Ba/F3) and investigated the range of interactions activated by the epidermal growth factor homology domain of the agonist neuregulin beta. The results provide the first comprehensive analysis of the response of this receptor family to a single peptide agonist. This peptide induced complex patterns of receptor tyrosine phosphorylation and regulation of Ba/F3 cell survival and proliferation. These data demonstrate the existence of several previously undocumented receptor interactions driven by neuregulin.

MeSH Terms
B-Lymphocytes Cell Count/drug effects Cell Line Cell Survival/drug effects Enzyme Activation ErbB Receptors/agonists,biosynthesis,genetics,metabolism Glycoproteins/chemical synthesis,pharmacology Humans Interleukin-3/pharmacology Neuregulins Peptides/chemical synthesis Phosphorylation Signal Transduction/drug effects
Chemicals
Glycoproteins Interleukin-3 Neuregulins Peptides ErbB Receptors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Riese D J
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.
van Raaij T M
Plowman G D
Andrews G C
Stern D F
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/MCB.15.10.5770
Published
1995-10-00
Pages
5770-6
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC230829
Subset
IM
Grants
NCI NIH HHS · CA-45708-06 · United States
NICHD NIH HHS · HD-07149 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/MCB.15.10.5770 PMC Full Text View journal details
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