Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.

Nature ·Vol. 362 ·No. 6418 ·1993-03-25 ·Pages 312-8

Marchionni MA, Goodearl AD, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M, Danehy F, Misumi D, Sudhalter J, Kobayashi K

Abstract

Glial growth factors, proteins that are mitogenic for Schwann cells, and several ligands for the p185erbB2 receptor, are products of the same gene. Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain. These factors are probably important in the development and regeneration of the nervous system.

MeSH Terms

Alternative Splicing Amino Acid Sequence Animals Base Sequence Brain/physiology Cattle Cells, Cultured Cloning, Molecular Glia Maturation Factor In Situ Hybridization Mice Molecular Sequence Data Nerve Tissue Proteins/metabolism Oncogene Proteins, Viral/metabolism Organ Specificity Phosphorylation RNA, Messenger/metabolism Receptor, ErbB-2 Schwann Cells/metabolism Spinal Cord/physiology

Chemicals

Glia Maturation Factor Nerve Tissue Proteins Oncogene Proteins, Viral RNA, Messenger Receptor, ErbB-2

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Marchionni M A

Cambridge NeuroScience Inc., Massachusetts 02139.

Goodearl A D

Chen M S

Bermingham-McDonogh O

Kirk C

Hendricks M

Danehy F

Misumi D

Sudhalter J

Kobayashi K

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/362312a0

Published

1993-03-25

Pages

312-8

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 8455712

External Links

PubMed source DOI: 10.1038/362312a0 View journal details

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Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.

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