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PMID: 1316471 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Herpes simplex virus type 1-mediated induction of human immunodeficiency virus type 1 provirus correlates with binding of nuclear proteins to the NF-kappa B enhancer and leader sequence.

Journal of virology ·Vol. 66 ·No. 6 ·1992-06-00 ·Pages 3616-23

Vlach J, Pitha PM

Abstract

Herpes simplex virus type 1 (HSV-1) infection induces expression of the human immunodeficiency virus type 1 (HIV-1) provirus in the chronically infected T-cell line ACH-2. The HSV-1-mediated induction correlates with the appearance of two NF-kappa B-specific proteins of 55 and 85 kDa in the nucleus and with the binding of 50-kDa nuclear protein to the LBP-1 binding site of the untranslated leader sequence of the HIV-1 long terminal repeat. The HSV-1-induced LBP-1 binding protein, designated HLP-1, is present exclusively in HSV-1-infected, but not in phorbol-12-myristate-13-acetate- or tumor necrosis factor alpha-treated ACH-2 cells. Both the NF-kappa B and LBP-1 target sequences, when inserted either alone or together 5' of a heterologous minimal promoter (thymidine kinase), confer inducibility by HSV-1 infection in a transient transfection assay. Thus, it appears that the HSV-1-mediated activation of HIV-1 provirus is brought about by the binding of both NF-kappa B and HLP-1 specific proteins to two distinct regions of HIV-1 long terminal repeat.

MeSH Terms
Acquired Immunodeficiency Syndrome/microbiology Base Sequence Cells, Cultured DNA, Recombinant DNA-Binding Proteins/metabolism HIV Enhancer/physiology HIV Long Terminal Repeat/physiology HIV-1/growth & development Humans Molecular Sequence Data Nuclear Proteins/metabolism Promoter Regions, Genetic Proviruses/growth & development Simplexvirus/metabolism T-Lymphocytes/microbiology Tetradecanoylphorbol Acetate/pharmacology Tumor Necrosis Factor-alpha/pharmacology Virus Activation/drug effects
Chemicals
DNA, Recombinant DNA-Binding Proteins Nuclear Proteins Tumor Necrosis Factor-alpha Tetradecanoylphorbol Acetate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vlach J
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231.
Pitha P M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.6.3616-3623.1992
Published
1992-06-00
Pages
3616-23
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241144
Subset
IM
Grants
NIAID NIH HHS · AI26123 · United States
NIAID NIH HHS · AI27297 · United States
External Links
PubMed source DOI: 10.1128/JVI.66.6.3616-3623.1992 PMC Full Text View journal details
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