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PMID: 2845125 Published · ppublish English Journal Article

Activation of the human immunodeficiency virus long terminal repeat by herpes simplex virus type 1 is associated with induction of a nuclear factor that binds to the NF-kappa B/core enhancer sequence.

Journal of virology ·Vol. 62 ·No. 11 ·1988-11-00 ·Pages 4104-12

Gimble JM, Duh E, Ostrove JM, Gendelman HE, Max EE, Rabson AB

Abstract

It has been previously shown that herpes simplex virus type 1 (HSV-1) infection of HeLa cells results in augmentation of gene expression directed by the human immunodeficiency virus (HIV) long terminal repeat (LTR). This effect is presumably mediated by protein interactions with the LTR. We have used two different assays of DNA-protein interactions to study the HSV-induced activation of the HIV LTR. Activation of the HIV LTR is associated with increased protein binding to LTR sequences in a region including the NF-kappa B/core enhancer and the Sp1 binding sequences as monitored by an exonuclease protection assay. Gel retardation assays demonstrated that HSV-1 infection resulted in the induction of a nuclear factor(s) that binds to the NF-kappa B/core enhancer sequence. In addition to the activation of the HIV LTR, HSV induction of NF-kappa B activity may be important for the regulation of HSV gene expression during a herpesvirus infection.

MeSH Terms
Base Sequence DNA-Binding Proteins/physiology Electrophoresis, Polyacrylamide Gel Enhancer Elements, Genetic Exonucleases HIV-1/genetics,growth & development Molecular Sequence Data Plasmids Repetitive Sequences, Nucleic Acid Simplexvirus/physiology Transcription Factors/physiology Transfection Virus Activation Virus Cultivation
Chemicals
DNA-Binding Proteins Transcription Factors Exonucleases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Gimble J M
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Duh E
Ostrove J M
Gendelman H E
Max E E
Rabson A B
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.11.4104-4112.1988
Published
1988-11-00
Pages
4104-12
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253841
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.62.11.4104-4112.1988 PMC Full Text View journal details
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