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PMID: 12142481 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Poliovirus cell entry: common structural themes in viral cell entry pathways.

Annual review of microbiology ·Vol. 56 ·2002-00-00 ·Pages 677-702

Hogle JM

Abstract

Structural studies of polio- and closely related viruses have provided a series of snapshots along their cell entry pathways. Based on the structures and related kinetic, biochemical, and genetic studies, we have proposed a model for the cell entry pathway for polio- and closely related viruses. In this model a maturation cleavage of a capsid protein precursor locks the virus in a metastable state, and the receptor acts like a transition-state catalyst to overcome an energy barrier and release the mature virion from the metastable state. This initiates a series of conformational changes that allow the virus to attach to membranes, form a pore, and finally release its RNA genome into the cytoplasm. This model has striking parallels with emerging models for the maturation and cell entry of more complex enveloped viruses such as influenza virus and HIV.

MeSH Terms
Capsid/chemistry,ultrastructure Humans Membrane Proteins Models, Genetic Models, Molecular Poliovirus/chemistry,metabolism,physiology,ultrastructure Receptors, Virus Virion/classification,genetics,metabolism Virus Integration
Chemicals
Membrane Proteins Receptors, Virus poliovirus receptor
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hogle James M
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA. hogle@hogles.med.harvard.edu
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Article Info
Journal
Annual review of microbiology
Abbr.
Annu Rev Microbiol
ISSN
0066-4227
DOI
10.1146/annurev.micro.56.012302.160757
Email
hogle@hogles.med.harvard.edu
Published
2002-00-00
Epub
2002-00-30
Pages
677-702
Language
English
Region
United States
NLM ID
0372370
PMCID
PMC1500891
Subset
IM
Grants
NIAID NIH HHS · R01 AI020566 · United States
NIAID NIH HHS · R21 AI020566 · United States
NIAID NIH HHS · R37 AI020566 · United States
NIAID NIH HHS · AI20566 · United States
External Links
PubMed source DOI: 10.1146/annurev.micro.56.012302.160757 PMC Full Text View journal details
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