Home LiteratureArticle Details
PMID: 8093643 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure of a human rhinovirus complexed with its receptor molecule.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 2 ·1993-01-15 ·Pages 507-11

Olson NH, Kolatkar PR, Oliveira MA, Cheng RH, Greve JM, McClelland A, Baker TS, Rossmann MG

Abstract

Cryoelectron microscopy has been used to determine the structure of a virus when complexed with its glycoprotein cellular receptor. Human rhinovirus 16 complexed with the two amino-terminal, immunoglobulin-like domains of the intercellular adhesion molecule 1 shows that the intercellular adhesion molecule 1 binds into the 12-A deep "canyon" on the viral surface. This result confirms the prediction that the viral-receptor attachment site lies in a cavity inaccessible to the host's antibodies. The atomic structures of human rhinovirus 14 and CD4, homologous to human rhinovirus 16 and intercellular adhesion molecule 1, showed excellent correspondence with observed density, thus establishing the virus-receptor interactions.

MeSH Terms
Antigens, CD/metabolism,ultrastructure CD4 Antigens/metabolism,ultrastructure Cell Adhesion Molecules/metabolism,ultrastructure Cryopreservation Humans Image Processing, Computer-Assisted Intercellular Adhesion Molecule-1 Microscopy, Electron Models, Molecular Receptors, Virus/metabolism,ultrastructure Rhinovirus/metabolism,ultrastructure
Chemicals
Antigens, CD CD4 Antigens Cell Adhesion Molecules Receptors, Virus Intercellular Adhesion Molecule-1
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Olson N H
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907-1392.
Kolatkar P R
Oliveira M A
Cheng R H
Greve J M
McClelland A
Baker T S
Rossmann M G
References (48)
48 references, click to expand
  1. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
    Cell. 1990 Apr 20;61(2):243-54 PMID: 1970514
  2. The major and minor group receptor families contain all but one human rhinovirus serotype.
    Virology. 1991 Feb;180(2):814-7 PMID: 1846502
  3. Functional domains of the poliovirus receptor.
    Proc Natl Acad Sci U S A. 1991 May 15;88(10):4104-8 PMID: 1851992
  4. Mutational analysis of the cellular receptor for poliovirus.
    J Virol. 1991 Jul;65(7):3873-6 PMID: 1645795
  5. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus.
    EMBO J. 1989 May;8(5):1567-79 PMID: 2548847
  6. The canyon hypothesis. Hiding the host cell receptor attachment site on a viral surface from immune surveillance.
    J Biol Chem. 1989 Sep 5;264(25):14587-90 PMID: 2670920
  7. Crystal structure of human rhinovirus serotype 1A (HRV1A).
    J Mol Biol. 1989 Nov 5;210(1):91-111 PMID: 2555523
  8. Localization of VP4 neutralization sites in rotavirus by three-dimensional cryo-electron microscopy.
    Nature. 1990 Feb 1;343(6257):476-9 PMID: 2153941
  9. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection.
    Nature. 1990 Mar 1;344(6261):70-2 PMID: 1968231
  10. Conformational variability of a picornavirus capsid: pH-dependent structural changes of Mengo virus related to its host receptor attachment site and disassembly.
    Virology. 1990 Mar;175(1):176-90 PMID: 2155508
  11. CD4: collaborator in immune recognition and HIV infection.
    Cell. 1990 Mar 9;60(5):697-700 PMID: 2107022
  12. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.
    Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5533-6 PMID: 1648219
  13. Three-dimensional structure of a mouse-adapted type 2/type 1 poliovirus chimera.
    EMBO J. 1991 Sep;10(9):2331-41 PMID: 1651227
  14. Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.
    Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7993-7 PMID: 1716769
  15. Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1.
    J Virol. 1991 Nov;65(11):6015-23 PMID: 1681115
  16. Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding.
    J Virol. 1991 Dec;65(12):6589-96 PMID: 1719231
  17. Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin.
    Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):324-8 PMID: 1729702
  18. Identification of a Fab interaction footprint site on an icosahedral virus by cryoelectron microscopy and X-ray crystallography.
    Nature. 1992 Jan 16;355(6357):275-8 PMID: 1731227
  19. Cauliflower mosaic virus: a 420 subunit (T = 7), multilayer structure.
    Virology. 1992 Feb;186(2):655-68 PMID: 1733107
  20. Structures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstruction.
    Biophys J. 1991 Dec;60(6):1445-56 PMID: 1663794
  21. Preliminary X-ray crystallographic analysis of intercellular adhesion molecule-1.
    J Mol Biol. 1992 Jun 20;225(4):1127-30 PMID: 1351949
  22. Treatment of the picornavirus common cold by inhibitors of viral uncoating and attachment.
    Annu Rev Microbiol. 1992;46:635-54 PMID: 1332585
  23. Identification of the residues in human CD4 critical for the binding of HIV.
    Cell. 1989 May 5;57(3):469-81 PMID: 2541915
  24. Many rhinovirus serotypes share the same cellular receptor.
    J Virol. 1984 Aug;51(2):340-5 PMID: 6086949
  25. Evidence for at least two dominant neutralization antigens on human rhinovirus 14.
    J Virol. 1985 Jan;53(1):137-43 PMID: 2981332
  26. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 PMID: 6096719
  27. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 PMID: 6083454
  28. Structure of a human common cold virus and functional relationship to other picornaviruses.
    Nature. 1985 Sep 12-18;317(6033):145-53 PMID: 2993920
  29. Three-dimensional structure of poliovirus at 2.9 A resolution.
    Science. 1985 Sep 27;229(4720):1358-65 PMID: 2994218
  30. [[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
    J Med Chem. 1985 Dec;28(12):1906-10 PMID: 2999407
  31. Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14.
    J Virol. 1986 Jan;57(1):246-57 PMID: 2416951
  32. The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.
    Science. 1986 Sep 19;233(4770):1286-93 PMID: 3018924
  33. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
    Cell. 1986 Nov 7;47(3):333-48 PMID: 3094962
  34. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.
    Nature. 1988 Feb 18;331(6157):624-7 PMID: 3340213
  35. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.
    Cell. 1988 Mar 25;52(6):925-33 PMID: 3349522
  36. Conservation of the putative receptor attachment site in picornaviruses.
    Virology. 1988 Jun;164(2):373-82 PMID: 2835857
  37. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid.
    Nature. 1988 Jun 2;333(6172):426-31 PMID: 3374584
  38. Evidence for the direct involvement of the rhinovirus canyon in receptor binding.
    Proc Natl Acad Sci U S A. 1988 Aug;85(15):5449-53 PMID: 2840661
  39. Biochemical characterization of a glycoprotein required for rhinovirus attachment.
    J Biol Chem. 1989 Jan 25;264(3):1656-62 PMID: 2536369
  40. The major human rhinovirus receptor is ICAM-1.
    Cell. 1989 Mar 10;56(5):839-47 PMID: 2538243
  41. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.
    Cell. 1989 Mar 10;56(5):849-53 PMID: 2538244
  42. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily.
    Cell. 1989 Mar 10;56(5):855-65 PMID: 2538245
  43. Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors.
    J Virol. 1989 May;63(5):2002-7 PMID: 2539499
  44. Antibodies that block rhinovirus attachment map to domain 1 of the major group receptor.
    J Virol. 1990 Jun;64(6):2582-7 PMID: 1970837
  45. Modeling of the human intercellular adhesion molecule-1, the human rhinovirus major group receptor.
    Proteins. 1990;7(3):227-33 PMID: 1972986
  46. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.
    Nature. 1990 Nov 29;348(6300):411-8 PMID: 1701030
  47. Crystal structure of an HIV-binding recombinant fragment of human CD4.
    Nature. 1990 Nov 29;348(6300):419-26 PMID: 2247146
  48. Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.
    J Virol. 1989 Jun;63(6):2476-85 PMID: 2542566
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.2.507
Published
1993-01-15
Pages
507-11
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC45692
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.90.2.507 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2