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PMID: 11894934 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mouse histocompatibility genes: structure and organisation of a Kd gene.

The EMBO journal ·Vol. 2 ·No. 2 ·1983-00-00 ·Pages 245-54

Kvist S, Roberts L, Dobberstein B

Abstract

The gene coding for the mouse H-2Kd antigen has been isolated by using a K-locus specific cDNA probe. The complete nucleotide sequence of the gene reveals eight exons separated by seven introns. Transcriptionally important DNA sequences (CCAAT and TATA) precede the first exon. Comparison with other H-2 genes shows extensive homology in exons as well as in introns. Two cDNA clones encoding Kd antigens have been analysed and provide evidence for at least two expressed Kd genes in the DBA/2 mouse. Comparison of the Kd antigen sequence to three other H-2 antigens indicates that gene conversion mechanism(s) act on H-2 genes. Analyses of exon donor and acceptor sites of different H-2 genes and cDNAs show that alternative splicing sites are used by different genes.

MeSH Terms
Alternative Splicing Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Probes Gene Conversion H-2 Antigens/genetics Histocompatibility Antigen H-2D Mice Mice, Inbred DBA Molecular Sequence Data Restriction Mapping Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Tumor Cells, Cultured
Chemicals
DNA Probes H-2 Antigens H-2K(K) antigen H-2Kb protein, mouse Histocompatibility Antigen H-2D
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kvist S
European Molecular Biology Laboratory, Heidelberg, FRG.
Roberts L
Dobberstein B
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1983-00-00
Pages
245-54
Language
English
Region
England
NLM ID
8208664
PMCID
PMC555121
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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