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PMID: 6461010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Exon/intron organization and complete nucleotide sequence of an HLA gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 3 ·1982-02-00 ·Pages 893-7

Malissen M, Malissen B, Jordan BR

Abstract

We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transmembrane region. The cytoplasmic segment is encoded by part of the fifth and the sixth and the seventh exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.

MeSH Terms
Bacteriophage lambda/genetics Base Sequence Cell Compartmentation Cloning, Molecular Genes HLA Antigens/genetics Humans Membrane Proteins/genetics Protein Precursors/genetics
Chemicals
HLA Antigens Membrane Proteins Protein Precursors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Malissen M
Malissen B
Jordan B R
References (28)
28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.3.893
Published
1982-02-00
Pages
893-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345859
Subset
IM
Databases
GENBANK
J00191
External Links
PubMed source DOI: 10.1073/pnas.79.3.893 PMC Full Text View journal details
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