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PMID: 92029 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 9 ·1979-09-00 ·Pages 4395-9

Orr HT, Lopez de Castro JA, Parham P, Ploegh HL, Strominger JL

Abstract

The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2Kb heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2Kb with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.

MeSH Terms
Amino Acid Sequence Cell Line Cyanogen Bromide Epitopes HLA Antigens/genetics,immunology Humans Macromolecular Substances Papain/metabolism Peptide Fragments/immunology Polymorphism, Genetic
Chemicals
Epitopes HLA Antigens Macromolecular Substances Peptide Fragments Papain Cyanogen Bromide
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Orr H T
Lopez de Castro J A
Parham P
Ploegh H L
Strominger J L
References (26)
26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.9.4395
Published
1979-09-00
Pages
4395-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411581
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.9.4395 PMC Full Text View journal details
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