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PMID: 1062804 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 73 ·No. 3 ·1976-03-00 ·Pages 910-4

Terhorst C, Parham P, Mann DL, Strominger JL

Abstract

Amino-acid and carbohydrate compositions in addition to limited NH2-terminal sequence data of four preparations of HLA antigens, including products of both of the major histocompatibility loci (HLA-A and HLA-B), show that the antigens have great homology in the primary structure. A striking observation is that HLA antigens also have a considerable structure homology with mouse H-2 antigens. HLA antigens appear to have one carbohydrate side chain which has the same composition in all four cases. The possible relation of the structure of the heavy chain of HLA antigens to immunoglobulins is discussed, based on the limited data which are available so far.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Carbohydrates/analysis Cell Line HLA Antigens/analysis,isolation & purification Histocompatibility Antigens/analysis Molecular Weight
Chemicals
Amino Acids Carbohydrates HLA Antigens Histocompatibility Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Terhorst C
Parham P
Mann D L
Strominger J L
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.73.3.910
Published
1976-03-00
Pages
910-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336029
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.73.3.910 PMC Full Text View journal details
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