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PMID: 53839 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 11 ·1975-11-00 ·Pages 4577-81

Armerding D, Kubo RT, Grey HM, Katz DH

Abstract

The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.

MeSH Terms
Animals B-Lymphocytes/immunology Beta-Globulins/immunology Cross Reactions Epitopes Histocompatibility Antigens Lymphocyte Activation Mice Mice, Inbred C3H Mice, Inbred DBA T-Lymphocytes/immunology beta 2-Microglobulin/immunology
Chemicals
Beta-Globulins Epitopes Histocompatibility Antigens beta 2-Microglobulin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Armerding D
Kubo R T
Grey H M
Katz D H
References (26)
26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.11.4577
Published
1975-11-00
Pages
4577-81
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388766
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.11.4577 PMC Full Text View journal details
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