Studies on the cytophilic properties of human beta2 microglobulin.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 114 ·No. 3 ·1975-03-00 ·Pages 997-1000

Anderson CL, Kubo RT, Grey HM

Abstract

Human beta2 microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more beta2 microblobulin than thymocytes although hydrocortisone-resistant thymocytes resemble spleen cells in this regard. The beta2 microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for beta2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.

MeSH Terms

Animals Anura B-Lymphocytes/immunology Beta-Globulins/immunology,isolation & purification Binding Sites, Antibody Chickens Drug Resistance Guinea Pigs Histocompatibility Antigens Humans Hydrocortisone/pharmacology Immune Sera Iodine Radioisotopes Kidney Transplantation Lymphocytes/drug effects,immunology Macrophages/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Myeloma Proteins/isolation & purification Rabbits Rats Species Specificity T-Lymphocytes/immunology Transplantation, Homologous Turtles Urine/analysis

Chemicals

Beta-Globulins Histocompatibility Antigens Immune Sera Iodine Radioisotopes Myeloma Proteins Hydrocortisone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Anderson C L

Kubo R T

Grey H M

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1975-03-00

Pages

997-1000

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

Analysis Services

Studies on the cytophilic properties of human beta2 microglobulin.

Contact

WeChat Official Account