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PMID: 11459950 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Historical overview: searching for replication help in all of the rec places.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 98 ·No. 15 ·2001-07-17 ·Pages 8173-80

Cox MM

Abstract

For several decades, research into the mechanisms of genetic recombination proceeded without a complete understanding of its cellular function or its place in DNA metabolism. Many lines of research recently have coalesced to reveal a thorough integration of most aspects of DNA metabolism, including recombination. In bacteria, the primary function of homologous genetic recombination is the repair of stalled or collapsed replication forks. Recombinational DNA repair of replication forks is a surprisingly common process, even under normal growth conditions. The new results feature multiple pathways for repair and the involvement of many enzymatic systems. The long-recognized integration of replication and recombination in the DNA metabolism of bacteriophage T4 has moved into the spotlight with its clear mechanistic precedents. In eukaryotes, a similar integration of replication and recombination is seen in meiotic recombination as well as in the repair of replication forks and double-strand breaks generated by environmental abuse. Basic mechanisms for replication fork repair can now inform continued research into other aspects of recombination. This overview attempts to trace the history of the search for recombination function in bacteria and their bacteriophages, as well as some of the parallel paths taken in eukaryotic recombination research.

MeSH Terms
Animals Bacteriophage T4/genetics DNA Nucleotidyltransferases/metabolism DNA Repair DNA Replication DNA, Viral/metabolism Eukaryotic Cells Genes, Bacterial Integrases Models, Genetic Prokaryotic Cells Rec A Recombinases/metabolism Recombinases Recombination, Genetic SOS Response, Genetics
Chemicals
DNA, Viral Recombinases DNA Nucleotidyltransferases Integrases Rec A Recombinases integron integrase IntI1
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cox M M
Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706-1544, USA. cox@biochem.wisc.edu
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.131004998
Email
cox@biochem.wisc.edu
Published
2001-07-17
Pages
8173-80
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC37418
Subset
IM
Grants
NIGMS NIH HHS · U01 GM032335 · United States
NIGMS NIH HHS · R01 GM052725 · United States
NIGMS NIH HHS · GM52725 · United States
NIGMS NIH HHS · GM32335 · United States
NIGMS NIH HHS · R01 GM032335 · United States
External Links
PubMed source DOI: 10.1073/pnas.131004998 PMC Full Text View journal details
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