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PMID: 9586242 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents.

Trends in biotechnology ·Vol. 16 ·No. 4 ·1998-04-00 ·Pages 190-6

Dinman JD, Ruiz-Echevarria MJ, Peltz SW

Abstract

Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production. Ribosomal frameshifting therefore provides a unique target on which antiviral agents can function. This article describes a series of rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed -1 ribosomal frameshifting.

MeSH Terms
Antiviral Agents/pharmacology Frameshifting, Ribosomal Virus Physiological Phenomena Viruses/drug effects
Chemicals
Antiviral Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dinman J D
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA.
Ruiz-Echevarria M J
Peltz S W
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Article Info
Journal
Trends in biotechnology
Abbr.
Trends Biotechnol
ISSN
0167-7799
DOI
10.1016/s0167-7799(97)01167-0
Published
1998-04-00
Pages
190-6
Language
English
Region
England
NLM ID
8310903
PMCID
PMC7127214
Grants
NIGMS NIH HHS · R01 GM048631 · United States
NIGMS NIH HHS · R01 GM058859 · United States
NIGMS NIH HHS · GM48631-01 · United States
External Links
PubMed source DOI: 10.1016/s0167-7799(97)01167-0 PMC Full Text View journal details
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