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PMID: 8619310 Published · ppublish English Journal Article Review

Ribosomal frameshifting in yeast viruses.

Yeast (Chichester, England) ·Vol. 11 ·No. 12 ·1995-09-30 ·Pages 1115-27

Dinman JD

Abstract

Proper maintenance of translational reading frame by ribosomes is essential for cell growth and viability. In the last 10 years it has been shown that a number of viruses induce ribosomes to shift reading frame in order to regulate the expression of gene products having enzymatic functions. Studies on ribosomal frameshifting in viruses of yeast have been particularly enlightening. The roles of viral mRNA sequences and secondary structures have been elucidated and a picture of how these interact with host chromosomal gene products is beginning to emerge. The efficiency of ribosomal frameshifting is important for viral particle assembly, and has identified ribosomal frameshifting as a potential target for antiviral agents. The availability of mutants of host chromosomal gene products involved in maintaining the efficiency of ribosomal frameshifting bodes well for the use of yeast in future studies of ribosomal frameshifting.

MeSH Terms
Amino Acid Sequence Base Sequence Frameshifting, Ribosomal Molecular Sequence Data RNA Viruses/genetics RNA, Double-Stranded/genetics RNA, Viral/genetics Saccharomyces cerevisiae/virology
Chemicals
RNA, Double-Stranded RNA, Viral
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Dinman J D
Section on Genetics of Simple Eukaryotes, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
References (56)
56 references, click to expand
  1. Translational frameshifting in the control of transposition in bacteria.
    Mol Microbiol. 1993 Feb;7(4):497-503 PMID: 8384687
  2. Yeast retrotransposons.
    Curr Opin Genet Dev. 1992 Oct;2(5):705-11 PMID: 1333855
  3. Interaction of two cis sites with the RNA replicase of the yeast L-A virus.
    J Biol Chem. 1992 Feb 5;267(4):2708-13 PMID: 1733966
  4. Host genes that influence transposition in yeast: the abundance of a rare tRNA regulates Ty1 transposition frequency.
    Proc Natl Acad Sci U S A. 1990 Nov;87(21):8360-4 PMID: 2172984
  5. K1 killer toxin, a pore-forming protein from yeast.
    Mol Microbiol. 1991 Oct;5(10):2339-43 PMID: 1724277
  6. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.
    Cell. 1988 Nov 4;55(3):447-58 PMID: 2846182
  7. Novel gene expression mechanism in a fission yeast retroelement: Tf1 proteins are derived from a single primary translation product.
    EMBO J. 1993 Dec;12(12):4885-95 PMID: 8223497
  8. Fungal virus capsids, cytoplasmic compartments for the replication of double-stranded RNA, formed as icosahedral shells of asymmetric Gag dimers.
    J Mol Biol. 1994 Dec 2;244(3):255-8 PMID: 7966336
  9. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme.
    Cell. 1995 Jan 13;80(1):51-60 PMID: 7813017
  10. Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):172-6 PMID: 8278359
  11. Ty element transposition: reverse transcriptase and virus-like particles.
    Cell. 1985 Sep;42(2):507-17 PMID: 2411424
  12. Ribosomal pausing during translation of an RNA pseudoknot.
    Mol Cell Biol. 1993 Nov;13(11):6931-40 PMID: 8413285
  13. Transposition of a Ty3 GAG3-POL3 fusion mutant is limited by availability of capsid protein.
    J Virol. 1992 Oct;66(10):6081-92 PMID: 1326658
  14. Gene overlap results in a viral protein having an RNA binding domain and a major coat protein domain.
    Cell. 1988 Nov 18;55(4):663-71 PMID: 2460245
  15. Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.
    Genes Dev. 1995 Feb 15;9(4):423-36 PMID: 7883167
  16. Alternative readings of the genetic code.
    Cell. 1993 Aug 27;74(4):591-6 PMID: 8358788
  17. Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast.
    Nature. 1985 Dec 12-18;318(6046):583-6 PMID: 2415827
  18. Special peptidyl-tRNA molecules can promote translational frameshifting without slippage.
    Mol Cell Biol. 1994 Dec;14(12):8107-16 PMID: 7969148
  19. RNA pseudoknots: translational frameshifting and readthrough on viral RNAs.
    Virus Genes. 1990 Jul;4(2):121-36 PMID: 2402881
  20. The coat protein of the yeast double-stranded RNA virus L-A attaches covalently to the cap structure of eukaryotic mRNA.
    Mol Cell Biol. 1992 Aug;12(8):3390-8 PMID: 1630453
  21. A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: frameshifting without tRNA slippage.
    Cell. 1993 Jul 16;74(1):93-103 PMID: 8267715
  22. Three different M1 RNA-containing viruslike particle types in Saccharomyces cerevisiae: in vitro M1 double-stranded RNA synthesis.
    Mol Cell Biol. 1986 May;6(5):1552-61 PMID: 3537705
  23. Ty element-induced temperature-sensitive mutations of Saccharomyces cerevisiae.
    Genetics. 1992 Aug;131(4):821-32 PMID: 1325386
  24. Post-transcriptional regulation of transposition by Ty retrotransposons of Saccharomyces cerevisiae.
    J Biol Chem. 1995 May 5;270(18):10361-4 PMID: 7737964
  25. Mutational analysis of the "slippery-sequence" component of a coronavirus ribosomal frameshifting signal.
    J Mol Biol. 1992 Sep 20;227(2):463-79 PMID: 1404364
  26. Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression.
    Proc Natl Acad Sci U S A. 1985 May;82(9):2829-33 PMID: 2581255
  27. Gene products that promote mRNA turnover in Saccharomyces cerevisiae.
    Mol Cell Biol. 1992 May;12(5):2165-77 PMID: 1569946
  28. Ty elements transpose through an RNA intermediate.
    Cell. 1985 Mar;40(3):491-500 PMID: 2982495
  29. Towards a genetic dissection of the basis of triplet decoding, and its natural subversion: programmed reading frame shifts and hops.
    Annu Rev Genet. 1991;25:201-28 PMID: 1812806
  30. Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting.
    Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3959-63 PMID: 8171019
  31. Mutational analysis of the RNA pseudoknot component of a coronavirus ribosomal frameshifting signal.
    J Mol Biol. 1991 Aug 20;220(4):889-902 PMID: 1880803
  32. A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.
    Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6587-91 PMID: 7604038
  33. Translational suppression in gene expression in retroviruses and retrotransposons.
    Curr Top Microbiol Immunol. 1990;157:93-124 PMID: 2168307
  34. Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene.
    Proc Natl Acad Sci U S A. 1982 Oct;79(19):5986-90 PMID: 6310558
  35. Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot.
    Cell. 1989 May 19;57(4):537-47 PMID: 2720781
  36. SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae.
    J Bacteriol. 1994 Nov;176(22):7126-8 PMID: 7961484
  37. Pulling the ribosome out of frame by +1 at a programmed frameshift site by cognate binding of aminoacyl-tRNA.
    Mol Cell Biol. 1995 Jan;15(1):298-304 PMID: 7799937
  38. Virus-like particles of yeast.
    Annu Rev Microbiol. 1980;34:49-68 PMID: 7002031
  39. Double-stranded and single-stranded RNA viruses of Saccharomyces cerevisiae.
    Annu Rev Microbiol. 1992;46:347-75 PMID: 1444259
  40. A -1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a gag-pol fusion protein.
    Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):174-8 PMID: 1986362
  41. Translational suppression in retroviral gene expression.
    Adv Virus Res. 1992;41:193-239 PMID: 1575083
  42. Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.
    Genetics. 1994 Jan;136(1):75-86 PMID: 8138178
  43. A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.
    Genetics. 1993 Oct;135(2):309-20 PMID: 8243996
  44. 5 S rRNA is involved in fidelity of translational reading frame.
    Genetics. 1995 Sep;141(1):95-105 PMID: 8536994
  45. Translation of the L-species dsRNA genome of the killer-associated virus-like particles of Saccharomyces cerevisiae.
    J Biol Chem. 1977 Dec 25;252(24):9010-7 PMID: 336627
  46. Ribosomal movement impeded at a pseudoknot required for frameshifting.
    Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8636-40 PMID: 1528874
  47. Identification and analysis of the gag-pol ribosomal frameshift site of feline immunodeficiency virus.
    Virology. 1992 Feb;186(2):389-97 PMID: 1310175
  48. RNA-dependent RNA polymerase consensus sequence of the L-A double-stranded RNA virus: definition of essential domains.
    Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2185-9 PMID: 1549580
  49. Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.
    J Virol. 1992 Jun;66(6):3669-76 PMID: 1583726
  50. Nonsense-mediated mRNA decay in yeast.
    Prog Nucleic Acid Res Mol Biol. 1994;47:271-98 PMID: 8016322
  51. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.
    Cell. 1983 May;33(1):153-9 PMID: 6678608
  52. The double-stranded RNA genome of yeast virus L-A encodes its own putative RNA polymerase by fusing two open reading frames.
    J Biol Chem. 1989 Apr 25;264(12):6716-23 PMID: 2651431
  53. Structural and functional aspects of RNA pseudoknots.
    Biochemistry. 1992 Dec 1;31(47):11665-76 PMID: 1280160
  54. Rapid and regulated degradation of ornithine decarboxylase.
    Biochem J. 1995 Feb 15;306 ( Pt 1):1-10 PMID: 7864793
  55. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.
    Genes Dev. 1995 Feb 15;9(4):437-54 PMID: 7883168
  56. Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site.
    Cell. 1990 Jul 27;62(2):339-52 PMID: 2164889
Article Info
Journal
Yeast (Chichester, England)
Abbr.
Yeast
ISSN
0749-503X
DOI
10.1002/yea.320111202
Published
1995-09-30
Pages
1115-27
Language
English
Region
England
NLM ID
8607637
PMCID
PMC7169727
Subset
IM
External Links
PubMed source DOI: 10.1002/yea.320111202 PMC Full Text View journal details
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