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PMID: 8718455 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans.

Journal of bioenergetics and biomembranes ·Vol. 27 ·No. 5 ·1995-10-00 ·Pages 499-512

Van Spanning RJ, de Boer AP, Reijnders WN, De Gier JW, Delorme CO, Stouthamer AH, Westerhoff HV, Harms N, van der Oost J

Abstract

Paracoccus denitrificans is a facultative anaerobic bacterium that has the capacity to adjust its metabolic infrastructure, quantitatively and/or qualitatively, to the prevailing growth condition. In this bacterium the relative activity of distinct catabolic pathways is subject to a hierarchical control. In the presence of oxygen the aerobic respiration, the most efficient way of electron transfer-linked phosphorylation, has priority. At high oxygen tensions P. denitrificans synthesizes an oxidase with a relatively low affinity for oxygen, whereas under oxygen limitation a high-affinity oxidase appears specifically induced. During anaerobiosis, the pathways with lower free energy-transducing efficiency are induced. In the presence of nitrate, the expression of a number of dehydrogenases ensures the continuation of oxidative phosphorylation via denitrification. After identification of the structural components that are involved in both the aerobic and the anaerobic respiratory networks of P. denitrificans, the intriguing next challenge is to get insight in its regulation. Two transcription regulators have recently been demonstrated to be involved in the expression of a number of aerobic and/or anaerobic respiratory complexes in P. denitrificans. Understanding of the regulation machinery is beginning to emerge and promises much excitement in discovery.

MeSH Terms
Aerobiosis Anaerobiosis Gene Expression Regulation, Bacterial Genes, Bacterial Homeostasis Models, Biological Mutagenesis Oxidative Phosphorylation Paracoccus denitrificans/genetics,growth & development,metabolism
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Van Spanning R J
Department of Microbial Physiology, Vrije Universiteit, Amsterdam, Netherlands.
de Boer A P
Reijnders W N
De Gier J W
Delorme C O
Stouthamer A H
Westerhoff H V
Harms N
van der Oost J
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Article Info
Journal
Journal of bioenergetics and biomembranes
Abbr.
J Bioenerg Biomembr
ISSN
0145-479X
DOI
10.1007/BF02110190
Published
1995-10-00
Pages
499-512
Language
English
Region
United States
NLM ID
7701859
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02110190 View journal details
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