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PMID: 8389455 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive multifocal leukoencephalopathy.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 90 ·No. 10 ·1993-05-15 ·Pages 4743-7

Wegner M, Drolet DW, Rosenfeld MG

Abstract

Progressive multifocal leukoencephalopathy results from an opportunistic infection of myelin-producing oligodendrocytes by the glia-specific human papovavirus JC. In this report, evidence is presented that the glial transcription factor Tst-1, a member of the POU-domain family, stimulates transcription of both early and late viral genes. Stimulation was dependent on site-specific binding of Tst-1 to the JC viral regulatory region and on the presence of an intact amino-terminal transactivation domain within Tst-1. Because of its ability to increase the expression of viral large tumor antigen, Tst-1 stimulated viral DNA replication, without participating directly in the replication event. Our results suggest that Tst-1 is one of the determining factors in the glia specificity of JC virus.

MeSH Terms
Base Sequence DNA-Binding Proteins/genetics Gene Expression Regulation, Viral Genes, Viral Humans In Vitro Techniques JC Virus/genetics,growth & development Leukoencephalopathy, Progressive Multifocal/genetics Molecular Sequence Data Nerve Tissue Proteins/genetics Octamer Transcription Factor-6 Oligodeoxyribonucleotides/chemistry Transcription Factors/genetics Transcription, Genetic Tumor Cells, Cultured Viral Proteins/genetics Viral Structural Proteins/genetics
Chemicals
DNA-Binding Proteins Nerve Tissue Proteins Oligodeoxyribonucleotides POU3F1 protein, human Transcription Factors Viral Proteins Viral Structural Proteins Octamer Transcription Factor-6
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wegner M
Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648.
Drolet D W
Rosenfeld M G
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.90.10.4743
Published
1993-05-15
Pages
4743-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC46589
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.90.10.4743 PMC Full Text View journal details
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