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PMID: 1977085 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

Nature ·Vol. 347 ·No. 6293 ·1990-10-11 ·Pages 528-33

Li S, Crenshaw EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG

Abstract

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.

Related Genes

pit-1

MeSH Terms

Amino Acid Sequence Animals Base Sequence Chromosome Mapping DNA-Binding Proteins/genetics Dwarfism, Pituitary/genetics Gene Expression Genes, Homeobox/genetics Growth Hormone/genetics Mice Mice, Inbred C3H Mice, Inbred Strains Molecular Sequence Data Mutation Nucleic Acid Hybridization Phenotype Pituitary Gland, Anterior/cytology,growth & development,metabolism Polymorphism, Restriction Fragment Length Prolactin/genetics Restriction Mapping Transcription Factor Pit-1 Transcription Factors/genetics

Chemicals

DNA-Binding Proteins Pit1 protein, mouse Transcription Factor Pit-1 Transcription Factors Prolactin Growth Hormone

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Li S

Department of Chemistry, University of California, San Diego, La Jolla 92093.

Crenshaw E B

Rawson E J

Simmons D M

Swanson L W

Rosenfeld M G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/347528a0

Published

1990-10-11

Pages

528-33

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/347528a0 View journal details

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

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