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PMID: 8143346 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

The Ras signal transduction pathway.

Cancer metastasis reviews ·Vol. 13 ·No. 1 ·1994-03-00 ·Pages 67-89

Khosravi-Far R, Der CJ

Abstract

Considerable progress has been made over the past year in elucidating the mechanisms by which extracellular signals are transduced via cell surface receptors to trigger changes in gene expression which determine the growth and differentiated state of a cell. In particular, Ras proteins have been implicated as key intermediates that mediate the signal from upstream tyrosine kinases to a downstream cascade of serine/threonine kinases, which then activate nuclear factors that control gene expression and protein synthesis. How Ras proteins function is regulated in this role as a molecular switch, and how the signal is transmitted between the various components of the pathway, are now being determined. Finally, the Rho family of Ras-related proteins, which regulate the actin cytoskeleton, have also been implicated as mediators of oncogenic Ras transformation. The brisk pace at which the key components of Ras-mediated signal transduction pathways are being identified hold great promise that new targets for therapeutic intervention in cancer may now be identified.

MeSH Terms
Animals Cell Differentiation Cell Division GTP-Binding Proteins/physiology Gene Expression Regulation Genes, ras Humans Mammals Mutation Neoplasms/genetics,pathology Oncogenes Proto-Oncogene Proteins p21(ras)/physiology Proto-Oncogenes Receptors, Cell Surface/physiology Signal Transduction
Chemicals
Receptors, Cell Surface GTP-Binding Proteins HRAS protein, human Proto-Oncogene Proteins p21(ras)
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Khosravi-Far R
Department of Pharmacology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599-7365.
Der C J
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00690419
Published
1994-03-00
Pages
67-89
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA42978 · United States
NCI NIH HHS · CA52072 · United States
NCI NIH HHS · CA55008 · United States
External Links
PubMed source DOI: 10.1007/BF00690419 View journal details
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