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PMID: 8479536 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Nature ·Vol. 363 ·No. 6424 ·1993-05-06 ·Pages 45-51

Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA

Abstract

The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.

MeSH Terms

Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Base Sequence Caenorhabditis elegans Cell Differentiation Cells, Cultured Cloning, Molecular DNA, Single-Stranded Drosophila ErbB Receptors/metabolism GRB2 Adaptor Protein Humans Membrane Proteins/metabolism Mice Molecular Sequence Data Protein Binding Protein-Tyrosine Kinases/metabolism Proteins/metabolism Proto-Oncogene Proteins p21(ras)/metabolism Rats Signal Transduction Son of Sevenless Proteins

Chemicals

Adaptor Proteins, Signal Transducing DNA, Single-Stranded GRB2 Adaptor Protein GRB2 protein, human Grb2 protein, mouse Grb2 protein, rat Membrane Proteins Proteins Son of Sevenless Proteins ErbB Receptors Protein-Tyrosine Kinases HRAS protein, human Proto-Oncogene Proteins p21(ras)

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Egan S E

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.

Giddings B W

Brooks M W

Buday L

Sizeland A M

Weinberg R A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/363045a0

Published

1993-05-06

Pages

45-51

Language

English

Region

England

NLM ID

0410462

Subset

Corrections

CommentIn

PMID: 8479530

External Links

PubMed source DOI: 10.1038/363045a0 View journal details

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

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