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PMID: 8483497 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

Nature ·Vol. 363 ·No. 6425 ·1993-05-13 ·Pages 133-40

Han M, Golden A, Han Y, Sternberg PW

Abstract

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

Related Genes
Ce-raf-1 lin-45 raf
MeSH Terms
Amino Acid Sequence Animals Base Sequence Caenorhabditis elegans/cytology,enzymology,genetics Caenorhabditis elegans Proteins Cell Differentiation/genetics Cloning, Molecular DNA Female Helminth Proteins/metabolism Humans Male Molecular Sequence Data Mutation Protein Serine-Threonine Kinases/genetics Proto-Oncogene Mas Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-raf Sequence Homology, Amino Acid Vulva/cytology ras Proteins
Chemicals
Caenorhabditis elegans Proteins Helminth Proteins MAS1 protein, human Proto-Oncogene Mas Proto-Oncogene Proteins let-60 protein, C elegans DNA Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-raf ras Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Han M
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.
Golden A
Han Y
Sternberg P W
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/363133a0
Published
1993-05-13
Pages
133-40
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
L15347
External Links
PubMed source DOI: 10.1038/363133a0 View journal details
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