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PMID: 8107195 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.

Journal of virology ·Vol. 68 ·No. 3 ·1994-03-00 ·Pages 1293-300

Justice MJ, Morse HC, Jenkins NA, Copeland NG

Abstract

We have identified a novel common site of ecotropic viral integration called ecotropic viral integration site 3 (Evi-3) in B-cell lineage lymphomas of the AKXD recombinant inbred strains of mice. A number of virally induced pre-B-, B-, myeloid, and T-cell lymphomas were screened for viral rearrangements at Evi-3; rearrangements were found in pre-B- and B-cell lymphomas but not in other hematopoietic tumors. Genetic mapping studies localized Evi-3 to mouse chromosome 18, distinct from proto-oncogene and common viral integration loci identified previously in the mouse. Each proviral integration at Evi-3 is contained within a 200-bp region that lies inside a CpG island. All but one of the proviruses have integrated in the same 5'-to-3' transcriptional orientation. Transcripts from Evi-3 are expressed in a developmentally regulated manner in B cells. Taken together, these data suggest that Evi-3 represents a novel proto-oncogene involved in mouse B-cell lymphomas.

MeSH Terms
Animals Chromosome Mapping Cloning, Molecular Crosses, Genetic DNA, Neoplasm/genetics Dinucleoside Phosphates/genetics Gene Rearrangement Lymphoma, B-Cell/genetics,microbiology Mice Mice, Inbred Strains Proto-Oncogenes/genetics Proviruses/genetics RNA, Messenger/analysis Restriction Mapping Retroviridae/genetics Virus Integration/genetics
Chemicals
DNA, Neoplasm Dinucleoside Phosphates RNA, Messenger cytidylyl-3'-5'-guanosine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Justice M J
Division of Biology, Kansas State University, Manhattan 66506.
Morse H C
Jenkins N A
Copeland N G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.68.3.1293-1300.1994
Published
1994-03-00
Pages
1293-300
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC236582
Subset
IM
Grants
NCI NIH HHS · 5F32CA08853-03 · United States
NIAID NIH HHS · N01-AI-72622 · United States
NCI NIH HHS · N01-CO-74101 · United States
External Links
PubMed source DOI: 10.1128/JVI.68.3.1293-1300.1994 PMC Full Text View journal details
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