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PMID: 7868598 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

bor gene of phage lambda, involved in serum resistance, encodes a widely conserved outer membrane lipoprotein.

Journal of bacteriology ·Vol. 177 ·No. 5 ·1995-03-00 ·Pages 1247-53

Barondess JJ, Beckwith J

Abstract

bor is one of two recently identified genes of phage lambda which are expressed during lysogeny and whose products display homology to bacterial virulence proteins. bor is closely related to the iss locus of plasmid CoIV,I-K94, which promotes bacterial resistance to serum complement killing in vitro and virulence in animals. bor has a similar in vitro effect. We show here that the bor gene product is a lipoprotein located in the Escherichia coli outer membrane. We also find that antigenically related proteins are expressed by lysogens of a number of other lambdoid coliphage, in cells carrying the cloned iss gene, and in several clinical isolates of E. coli. These results demonstrate that bor sequences are widespread and present a starting point for mechanistic analysis of bor-mediated serum resistance.

Related Genes
bor
MeSH Terms
Amino Acid Sequence Bacterial Outer Membrane Proteins/genetics,immunology,isolation & purification Bacterial Proteins/genetics Bacteriocin Plasmids/genetics Bacteriophage lambda/genetics Blood Bactericidal Activity/genetics Cell Compartmentation Cross Reactions Escherichia coli/pathogenicity,virology Lipoproteins/genetics,immunology,isolation & purification Molecular Sequence Data Viral Proteins/genetics,immunology,isolation & purification Virulence/genetics
Chemicals
Bacterial Outer Membrane Proteins Bacterial Proteins Lipoproteins Viral Proteins bor protein, Bacteriophage lambda
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Barondess J J
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Beckwith J
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.177.5.1247-1253.1995
Published
1995-03-00
Pages
1247-53
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC176730
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.177.5.1247-1253.1995 PMC Full Text View journal details
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