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PMID: 7035371 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Further characterization of complement resistance conferred on Escherichia coli by the plasmid genes traT of R100 and iss of ColV,I-K94.

Infection and immunity ·Vol. 35 ·No. 2 ·1982-02-00 ·Pages 654-9

Binns MM, Mayden J, Levine RP

Abstract

We have shown that the traT gene product was responsible for the complement resistance of the R100 plasmid. We compared this resistance with that specified by the iss gene of the ColV,I-K94 plasmid. The levels of resistance specified by the two genes were similar, and there was no additive effect on resistance when both genes were present together. Under conditions in which traT and iss conferred at least a 50- and 10-fold increase in survival, respectively, the consumption of C6, C7, C8, and C9 was the same for bacteria with and without the plasmid genes. This result indicated that it was the action of the terminal complex, not its formation, which was blocked by traT and iss.

MeSH Terms
Bacteriocin Plasmids Cloning, Molecular Complement Activation Complement System Proteins/metabolism Escherichia coli/genetics Genes, Bacterial Plasmids R Factors
Chemicals
Complement System Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Binns M M
Mayden J
Levine R P
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.35.2.654-659.1982
Published
1982-02-00
Pages
654-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC351091
Subset
IM
Grants
NIAID NIH HHS · AI 16475 · United States
External Links
PubMed source DOI: 10.1128/iai.35.2.654-659.1982 PMC Full Text View journal details
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