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PMID: 7038392 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Recombination and mutagenesis in rad6 mutants of Saccharomyces cerevisiae: evidence for multiple functions of the RAD6 gene.

Molecular & general genetics : MGG ·Vol. 184 ·No. 3 ·1981-00-00 ·Pages 410-5

Montelone BA, Prakash S, Prakash L

Abstract

The rad6-1 and rad6-3 mutants are highly UV sensitive and show an increase in spontaneous and UV induced mitotic heteroallelic recombination in diploids. Both rad6 mutants are proficient in spontaneous and UV induced unequal sister chromatid recombination in the reiterated ribosomal DNA sequence and are deficient in UV induced mutagenesis. In contrast to the above effects where both mutants appear similar, rad6-1 mutants are deficient in sporulation and meiotic recombination whereas rad6-3 mutants are proficient. The differential effects of these mutations indicate that the RAD6 gene is multifunctional. The possible role of the RAD6 gene in error prone excision repair of UV damage during the G1 phase of the cell cycle in addition to its role in postreplication repair is discussed.

MeSH Terms
Alleles Dose-Response Relationship, Radiation Genes Genotype Meiosis Mitosis/radiation effects Mutation Recombination, Genetic Saccharomyces cerevisiae/genetics,radiation effects Sister Chromatid Exchange/radiation effects Ultraviolet Rays
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Montelone B A
Prakash S
Prakash L
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39 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00352514
Published
1981-00-00
Pages
410-5
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Grants
NIGMS NIH HHS · GM19261 · United States
External Links
PubMed source DOI: 10.1007/BF00352514
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