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PMID: 6969580 Published · ppublish English Journal Article

Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains.

Antimicrobial agents and chemotherapy ·Vol. 18 ·No. 5 ·1980-11-00 ·Pages 837-8

Toda M, Sato K, Nakazawa H, Inoue M, Mitsuhashi S

Abstract

N-Formimidoyl thienamycin (MK0787) was active against beta-lactamase-producing strains and was an effective inhibitor of beta-lactamases extracted and purified from these strains except for plasmid-mediated penicillinase type IV.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects,enzymology Drug Resistance, Microbial Imipenem beta-Lactamase Inhibitors beta-Lactamases/metabolism beta-Lactams/pharmacology
Chemicals
Anti-Bacterial Agents beta-Lactamase Inhibitors beta-Lactams Imipenem beta-Lactamases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Toda M
Sato K
Nakazawa H
Inoue M
Mitsuhashi S
References (12)
12 references, click to expand
  1. The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.
    J Biochem. 1969 Jul;66(1):11-20 PMID: 4980693
  2. Variant of penicillinase mediated by an R factor in Escherichia coli.
    J Bacteriol. 1970 Nov;104(2):620-9 PMID: 4923065
  3. Comparison of assay techniques for beta-lactamase activity.
    Anal Biochem. 1973 Jul;54(1):9-16 PMID: 4725679
  4. A spectrophotometric assay of beta-lactamase action on penicillins.
    Biochem J. 1974 Jun;139(3):789-90 PMID: 4368359
  5. Beta-lactamase formation and resistance of Proteus morganii to various penicillins and cephalosporins.
    Jpn J Microbiol. 1974 Mar;18(2):113-8 PMID: 4497004
  6. Biochemical properties of a penicillin beta-lactamase mediated by R factor from Bordetella bronchiseptica.
    Antimicrob Agents Chemother. 1975 Sep;8(3):238-42 PMID: 241286
  7. Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1976 Jan;9(1):55-60 PMID: 4010
  8. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.
    Antimicrob Agents Chemother. 1977 May;11(5):852-7 PMID: 879738
  9. Purification and properties of beta-lactamase from Proteus morganii.
    J Bacteriol. 1977 Sep;131(3):726-34 PMID: 70426
  10. In vitro activity of thienamycin.
    Antimicrob Agents Chemother. 1978 Sep;14(3):436-8 PMID: 708019
  11. Clavulanic acid, a novel inhibitor of beta-lactamases.
    Antimicrob Agents Chemother. 1978 Nov;14(5):650-5 PMID: 310279
  12. Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.
    Antimicrob Agents Chemother. 1979 Apr;15(4):518-21 PMID: 380462
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.18.5.837
Published
1980-11-00
Pages
837-8
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284101
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.18.5.837 PMC Full Text View journal details
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