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PMID: 6954511 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 12 ·1982-06-00 ·Pages 3687-91

Larhammar D, Schenning L, Gustafsson K, Wiman K, Claesson L, Rask L, Peterson PA

Abstract

The complete nucleotide sequence of an HLA-DR antigen-like beta-chain cDNA clone was determined. The 1,080 base pairs include the complete coding region and most of the untranslated portion. The predicted amino acid sequence has 229 residues. The beta chain contains two immunoglobulin-like disulfide loops and a 21-amino acid residue membrane-integrated segment. Ten amino acid residues reside on the cytoplasmic side of the plasma membrane. The single asparagine-linked carbohydrate moiety is attached to asparagine-19. The NH2-terminal 91 residues of the beta chain are homologous to the corresponding region of HLA-A, -B, and -C antigen heavy chains. Residues 92-192 of the beta chain display statistically significant homology to members of the immunoglobulin family, beta 2-microglobulin, and the immunoglobulin-like domain of HLA-A, -B, and -C antigen heavy chains. These data establish that the major histocompatibility antigens of class I and class II type and the constant regions of immunoglobulins are evolutionarily related.

MeSH Terms
Amino Acid Sequence Base Sequence HLA Antigens HLA-DR Antigens Histocompatibility Antigens Class II/genetics Humans Immunoglobulins/genetics Macromolecular Substances Membrane Proteins RNA, Messenger/genetics
Chemicals
HLA Antigens HLA-DR Antigens Histocompatibility Antigens Class II Immunoglobulins Macromolecular Substances Membrane Proteins RNA, Messenger
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Larhammar D
Schenning L
Gustafsson K
Wiman K
Claesson L
Rask L
Peterson P A
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45 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.12.3687
Published
1982-06-00
Pages
3687-91
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346491
Subset
IM
Databases
GENBANK
J00198
External Links
PubMed source DOI: 10.1073/pnas.79.12.3687 PMC Full Text View journal details
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