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PMID: 6381555 Published · ppublish English Journal Article Review

Clinical and biological significance of aneuploidy in human tumours.

Journal of clinical pathology ·Vol. 37 ·No. 9 ·1984-09-00 ·Pages 961-74

Friedlander ML, Hedley DW, Taylor IW

Abstract

Aneuploidy is a well recognised feature of human tumours, but the investigation of its biological and clinical significance has been hampered by technological constraints. Quantitative DNA analysis reflects the total chromosomal content of tumour cells and can now be determined rapidly and reliably using flow cytometry; this has resulted in renewed interest in its potential clinical applications. This article reviews the accumulating evidence that tumour ploidy reflects the biological behaviour of a large number of tumour types and that diploid tumours in particular have a relatively good prognosis. The measurement of tumour ploidy is likely to become a valuable adjunct to the clinical and histopathological assessment of cancers.

MeSH Terms
Aneuploidy Bone Neoplasms/genetics Brain Neoplasms/genetics Chromosomes, Human Colonic Neoplasms/genetics Cytological Techniques DNA, Neoplasm/analysis Diploidy Female Flow Cytometry Genital Neoplasms, Female/genetics Humans Lung Neoplasms/genetics Lymphoproliferative Disorders/genetics Male Melanoma/genetics Neoplasms/analysis,genetics Prognosis Urogenital Neoplasms/genetics
Chemicals
DNA, Neoplasm
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Friedlander M L
Hedley D W
Taylor I W
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.37.9.961
Published
1984-09-00
Pages
961-74
Language
English
Region
England
NLM ID
0376601
PMCID
PMC498910
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.37.9.961 PMC Full Text View journal details
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