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PMID: 7469203 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Relationship between nuclear DNA distribution and estrogen receptors in human mammary carcinomas.

Analytical and quantitative cytology ·Vol. 2 ·No. 4 ·1980-12-00 ·Pages 280-4

Auer GU, Caspersson TO, Gustafsson SA, Humla SA, Ljung BM, Nordenskjöld BA, Silfverswärd C, Wallgren AS

Abstract

The relationship between DNA distribution pattern and estrogen receptor (ER) content was investigated in primary mammary carcinomas from 56 female patients. The data showed that mammary carcinomas in which the DNA amounts of the tumor cells do not deviate conspicuously from diploid or tetraploid DNA values of normal mammary epithelium are characterized by high levels of ER. On the other hand, mammary carcinomas containing a sizable number of cells with DNA amounts in the normal DNA synthesis region or with high degrees of aneuploidy are distinguished by low or even unmeasurable ER levels. These results strongly indicate a correlation between nuclear DNA distribution patterns and ER levels in primary breast carcinomas.

Keywords

Biology Breast Cancer--analysis Cancer Clinical Research Diseases Hormone Receptors Hormones Membrane Proteins Neoplasms Physiology Research Methodology

MeSH Terms

Breast Neoplasms/analysis DNA, Neoplasm/analysis Epithelium/analysis Female Histocytochemistry Humans Menopause Middle Aged Receptors, Estrogen/analysis

Chemicals

DNA, Neoplasm Receptors, Estrogen

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Auer G U

Caspersson T O

Gustafsson S A

Humla S A

Ljung B M

Nordenskjöld B A

Silfverswärd C

Wallgren A S

Other Abstracts

eng

An investigation was conducted to determine if a relationship exists between the estrogen receptor (ER) content and the type of nuclear DNA distribution patterns in human mammary carcinomas. Primary breast carcinomas from 56 female patients (52 postmenopausal and 4 premenopausal women) were examined. All cases were treated by mastectomy or local excision, and none of the patients had received any treatment for their disease before cell sampling for DNA and ER analysis was performed. The DNA histograms of these tumors could be grouped into 4 distinctly different classes or types: type 1 is characterized by a single modal DNA value in the normal diploid or near-diploid region

histograms of type 2 have a distinct single modal value in the normal tetraploid or near-tetraploid region or pronounced peaks in the 2c region as well as in the 4c region

type 3 populations differ from type 2 populations by showing a sizable number of cells in the normal DNA synthesis region

and the type 4 histograms are characterized by pronounced irregular aneuploidy, with individual DNA values ranging from levels near 2c up to values beyond 6c or even 8c. The data showed that mammary carcinomas in which the DNA amounts of the tumor cells do not deviate conspicuously from diploid or tetraploid DNA values of normal mammary epithelium were characterized by high levels of ER. Mammary carcinomas which contained a sizable number of cells with DNA amounts in the normal DNA synthesis region or with high degrees of aneuploidy were distinguished by low or even unmeasurable ER levels. The findings indicate a correlation between nuclear DNA distribution patterns and ER levels in primary breast carcinoma.

Article Info

Journal

Analytical and quantitative cytology

Abbr.

Anal Quant Cytol

ISSN

0190-0471

Published

1980-12-00

Pages

280-4

Language

English

Region

United States

NLM ID

7911206

Subset

Grants

NCI NIH HHS · N01-CB-43945 · United States

External Links

PubMed source

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Relationship between nuclear DNA distribution and estrogen receptors in human mammary carcinomas.

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