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PMID: 6350828 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Trp repressor protein is capable of intruding into other amino acid biosynthetic systems.

Molecular & general genetics : MGG ·Vol. 191 ·No. 1 ·1983-00-00 ·Pages 51-8

Bogosian G, Somerville R

Abstract

Escherichia coli strains with elevated intracellular levels of Trp repressor protein displayed complete growth inhibition on minimal media which contained high levels of tryptophan. The inhibition was attributable to the acquisition of a compound nutritional requirement, which could be satisfied by a combination of isoleucine, leucine, valine, threonine, serine, phenylalanine, and tyrosine. It is proposed that Trp repressor protein, at elevated levels, represses the transcription of those genes which encode enzymes for the biosynthesis of these particular amino acids. Data which support this model are presented, together with a discussion of its regulatory implications.

MeSH Terms
Amino Acids/biosynthesis Cross Reactions Escherichia coli/genetics Repressor Proteins/pharmacology Transcription Factors/pharmacology Transcription, Genetic/drug effects Tryptophan/genetics
Chemicals
Amino Acids Repressor Proteins Transcription Factors Tryptophan
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bogosian G
Somerville R
References (41)
41 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00330889
Published
1983-00-00
Pages
51-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Grants
NIGMS NIH HHS · GM22131 · United States
External Links
PubMed source DOI: 10.1007/BF00330889
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