Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.

Journal of bacteriology ·Vol. 97 ·No. 3 ·1969-03-00 ·Pages 1234-41

Wallace BJ, Pittard J

Abstract

Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.

MeSH Terms

Chromatography Conjugation, Genetic Enzyme Repression Escherichia coli/enzymology,growth & development Genes, Regulator Genetics, Microbial Heptoses/biosynthesis Hydro-Lyases/metabolism Isomerases/metabolism Ligases/analysis,metabolism Molecular Biology Mutation Selection, Genetic Transaminases/metabolism Transduction, Genetic Tyrosine/biosynthesis,pharmacology

Chemicals

Heptoses Tyrosine Transaminases Hydro-Lyases Isomerases Ligases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wallace B J

Pittard J

References (14)

14 references, click to expand

Control of aromatic biosynthesis: the multiplicity of 7-phospho-2-oxo-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) in Escherichia coli W.
Biochim Biophys Acta. 1965 Jul 8;104(2):377-89 PMID: 5322804
Activation of tyrosine analogs in relation to enzyme repression.
Biochem Biophys Res Commun. 1965 Jul 26;20(3):352-9 PMID: 5323176
Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli.
J Bacteriol. 1966 Apr;91(4):1494-508 PMID: 5326114
Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli.
J Bacteriol. 1967 Jan;93(1):237-44 PMID: 5335890
Chromatography of 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthetase (trp) on diethylaminoethyl cellulose: a correction.
J Bacteriol. 1967 Oct;94(4):1279-80 PMID: 4860915
Regulation of aromatic amino acid biosynthesis Escherichia coli K12.
Genetics. 1968 Sep;60(1):31-48 PMID: 4884590
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Genetic variation in the sex factor of Escherichia coli.
J Bacteriol. 1960 Mar;79:321-30 PMID: 13791860
The control of 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthesis by phenylalanine and tyrosine.
J Biol Chem. 1962 Nov;237:3566-70 PMID: 13989507
Repression of transaminase A by tyrosine in Escherichia coli.
Biochim Biophys Acta. 1963 Jun 11;73:232-40 PMID: 13992838
END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W.
Biochim Biophys Acta. 1963 Sep 3;77:170-2 PMID: 14078968
GENE TRANSFER BY F' STRAINS OF ESCHERICHIA COLI K-12. III. AN ANALYSIS OF THE RECOMBINATION EVENTS OCCURRING IN THE F' MALE AND IN THE ZYGOTES.
Genetics. 1964 Jun;49:995-1007 PMID: 14181492
THE EFFECTS OF PHENYLALANINE AND TYROSINE ANALOGS ON THE SYNTHESIS AND ACTIVITY OF 3-DEOXY-D-ARABINO-HEPTULOSONIC ACID 7-PHOSPHATE SYNTHETASES.
Arch Biochem Biophys. 1964 May;105:424-30 PMID: 14186748
THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE.
Biochim Biophys Acta. 1965 Apr 12;100:76-88 PMID: 14323651

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.97.3.1234-1241.1969

Published

1969-03-00

Pages

1234-41

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC249840

Subset

External Links

PubMed source DOI: 10.1128/jb.97.3.1234-1241.1969 PMC Full Text View journal details

Analysis Services

Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.

Contact

WeChat Official Account