Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli.

Journal of bacteriology ·Vol. 91 ·No. 4 ·1966-04-00 ·Pages 1494-508

Pittard J, Wallace BJ

Abstract

Pittard, James (School of Microbiology, University of Melbourne, Victoria, Australia), and B. J. Wallace. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J. Bacteriol. 91:1494-1508. 1966.-A number of mutant strains of Escherichia coli K-12, which are blocked in the biosynthesis of the aromatic amino acids, were examined biochemically to determine their particular enzymatic deficiencies. The mutations carried by these strains were mapped by use of the methods of conjugation and transduction. Structural genes for five of the enzymes of the common pathway leading to chorismate and for the two enzymes converting chorismate to phenylpyruvate and p-hydroxyphenylpyruvate, respectively, were identified. Unlike the genes of the tryptophan operon most of these genes are distributed over widely separated regions of the chromosome.

MeSH Terms

Amino Acids/biosynthesis Chromatography Chromosome Mapping Escherichia coli/enzymology,metabolism Genes Hydro-Lyases In Vitro Techniques Kinetics Mutation Phenylpyruvic Acids/metabolism Shikimic Acid/metabolism

Chemicals

Amino Acids Phenylpyruvic Acids Shikimic Acid Hydro-Lyases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Pittard J

Wallace B J

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21 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.91.4.1494-1508.1966

Published

1966-04-00

Pages

1494-508

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC316068

Subset

External Links

PubMed source DOI: 10.1128/jb.91.4.1494-1508.1966 PMC Full Text View journal details

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Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli.

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