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PMID: 6322120 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.

Nucleic acids research ·Vol. 12 ·No. 4 ·1984-02-24 ·Pages 1767-78

Chen HR, Barker WC

Abstract

The nucleotide sequences of the LTRs and their adjacent regions from 19 type C and one type B retrovirus were compared. Salient features are: (a) The R regions in the genomes of most of the type C retroviruses begin with GC and end with CA. (b) The mammalian type C retroviruses have a polyadenylation signal "AATAAA" in the R region, and most have a "CAT" box and a "TATA" box in the U3 region. (c) The avian type C retroviruses have an AATAAA sequence, and some also have "CAT-like" and "TATA-like" boxes, in the U3 region. (d) As with many transposable elements, the IR regions of the proviruses begin with TG and end with CA, and the DR sequences in the host genomes flanking the proviruses are different from one another. Although SNV is an avian retrovirus, the nucleotide sequences in the R, U5, TBS, and PU region are more similar to the mammalian type C than to the avian type C retroviruses.

MeSH Terms
Animals Base Sequence Genes, Viral Humans Repetitive Sequences, Nucleic Acid Retroviridae/genetics Species Specificity
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chen H R
Barker W C
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47 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.4.1767
Published
1984-02-24
Pages
1767-78
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318619
Subset
IM
Grants
NIGMS NIH HHS · GM08710 · United States
External Links
PubMed source DOI: 10.1093/nar/12.4.1767 PMC Full Text View journal details
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