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PMID: 6172779 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure of the baboon endogenous virus genome: nucleotide sequences of the long terminal repeat.

Nucleic acids research ·Vol. 9 ·No. 23 ·1981-12-11 ·Pages 6615-26

Tamura T, Noda M, Takano T

Abstract

The entire nucleotide sequence of the long terminal repeat (LTR) of baboon endogenous virus (BaEV) M7 was determined, which consisted of 554 base pairs (bp). At both ends of the LTR, 13 bp sequences, AAATGAAAAGTAA and TGATTCTAACATC, were detected to be inverted repeats. The structure with these inverted repeats resembles those of other retroviruses and transposable elements. a Hogness box, TATAAAA, and a putative poly(A)-addition signal, AGTAAA, were present within the right-hand half of the LTR, where the initiation and termination of the viral RNA synthesis seems to occur in the integrated BaEV genome. The primer-binding site of at least 14 bp long was found just outside of the LTR where the strong stop DNA started, and the primer for reverse transcription in BaEV seemed to be tRNAPro. Several structural features are commonly detected in the LTRs of BaEV and other retroviruses. Our studies suggest that BaEV has evolved from a common ancestor with other mammalian type C viruses. Close relationships between BaEV and a feline endogenous virus, RD114, are demonstrated.

MeSH Terms
Cloning, Molecular DNA Restriction Enzymes DNA Viruses/genetics Genes, Viral Plasmids RNA-Directed DNA Polymerase/metabolism Repetitive Sequences, Nucleic Acid Transcription, Genetic
Chemicals
RNA-Directed DNA Polymerase DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tamura T
Noda M
Takano T
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33 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/9.23.6615
Published
1981-12-11
Pages
6615-26
Language
English
Region
England
NLM ID
0411011
PMCID
PMC327626
Subset
IM
Databases
GENBANK
J02037
External Links
PubMed source DOI: 10.1093/nar/9.23.6615 PMC Full Text View journal details
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