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PMID: 6276685 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA repair in E. coli strains deficient in single-strand DNA binding protein.

Molecular & general genetics : MGG ·Vol. 183 ·No. 2 ·1981-00-00 ·Pages 341-7

Whittier RF, Chase JW

Abstract

Weigle reactivation and mutagenesis have been found to be defective in strains of E. coli deficient in single-strand DNA binding protein (SSB). These defects parallel those previously found in prophage induction and amplification of recA protein synthesis in ssb- strains. Together, these results demonstrate a role for SSB in the induction of SOS responses. UV survival studies of ssb- recA- and ssb- uvr- strains are presented which also suggest a role for SSB in recombinational repair processes but not in excision repair. Studies of host cell reactivation support this latter conclusion.

MeSH Terms
DNA Helicases/genetics DNA Repair/radiation effects DNA, Single-Stranded/genetics Escherichia coli/genetics Phenotype Recombination, Genetic Ultraviolet Rays
Chemicals
DNA, Single-Stranded DNA Helicases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Whittier R F
Chase J W
References (31)
31 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00270638
Published
1981-00-00
Pages
341-7
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
Grants
NCI NIH HHS · CA13330 · United States
PHS HHS · GA11301 · United States
NIGMS NIH HHS · GM23451 · United States
External Links
PubMed source DOI: 10.1007/BF00270638
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