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PMID: 227832 Published · ppublish English Journal Article

Mutant single-strand binding protein of Escherichia coli: genetic and physiological characterization.

Journal of bacteriology ·Vol. 140 ·No. 1 ·1979-10-00 ·Pages 14-9

Glassberg J, Meyer RR, Kornberg A

Abstract

A mutation in the Escherichia coli gene for single-strand binding protein results in temperature-sensitive deoxyribonucleic acid replication (R. R. Meyer, J. Glassberg, and A. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 76:1702-1705, 1979). The mutant (ssb-1) is also more sensitive to ultraviolet irradiation and about one-fifth as active in recombination. Single-strand binding protein is thus implicated in repair and recombination as well as in replication. The mutation in ssb is located between uvrA and melA at 90.8 min on the genetic map. The ssb gene appears to be allelic with lexC, a gene with a proposed role in regulating inducible deoxyribonucleic acid repair.

MeSH Terms
Bacterial Proteins/genetics,physiology Chromosome Mapping DNA Helicases/genetics,physiology DNA Repair DNA, Bacterial/biosynthesis Escherichia coli/physiology Genes Recombination, Genetic
Chemicals
Bacterial Proteins DNA, Bacterial DNA Helicases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Glassberg J
Meyer R R
Kornberg A
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25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.140.1.14-19.1979
Published
1979-10-00
Pages
14-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC216773
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.140.1.14-19.1979 PMC Full Text View journal details
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