Home LiteratureArticle Details
PMID: 77015 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Early events and mechanisms in the induction of bacterial SOS functions: analysis of the phage repressor inactivation process in vivo.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 4 ·1978-04-00 ·Pages 1657-61

Smith CL, Oishi M

Abstract

Different inducing agents and treatments produced distinctly different kinetic patterns of inactivation of prophage repressor molecules. The different patterns were related to differences in the initial altered states of DNA that were produced. The timing of appearance of DNA degradation was correlated with the time needed for repressor inactivation. These characteristics suggest that all the inducing treatments lead to the formation of a final predegradative DNA structure(s) (probably involving scissions) that is acted on by specific DNases, including the recBC DNase, to produce the signals for the induction of prophage.

MeSH Terms
Bleomycin/pharmacology Colicins/pharmacology Coliphages/metabolism Deoxyribonucleases/metabolism Kinetics Lysogeny/drug effects Mitomycins/pharmacology Mutation Streptonigrin/pharmacology Viral Proteins/metabolism Virus Replication/drug effects
Chemicals
Colicins Mitomycins Viral Proteins Bleomycin Streptonigrin Deoxyribonucleases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith C L
Oishi M
References (26)
26 references, click to expand
  1. Colicin E2 is DNA endonuclease.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3989-93 PMID: 1069283
  2. Model for regulation of Escherichia coli DNA repair functions.
    Proc Natl Acad Sci U S A. 1975 Jun;72(6):2330-4 PMID: 1094463
  3. Phileomycin-induced lethality and DNA degradation in Escherichia coli K12.
    Mutat Res. 1975 Jul;29(1):21-31 PMID: 1097910
  4. Isolation and identification of the irradiation product of thymine.
    Biochim Biophys Acta. 1960 Jul 15;41:550-1 PMID: 13800233
  5. A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS.
    Proc Natl Acad Sci U S A. 1963 Aug;50:355-62 PMID: 14060656
  6. A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):1152-6 PMID: 322145
  7. Metabolic characterization of the viable, residually dividing and nondividing cell classes of recombination-deficient strains of Escherichia coli.
    J Bacteriol. 1977 Apr;130(1):160-6 PMID: 323225
  8. Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction.
    Proc Natl Acad Sci U S A. 1977 Jun;74(6):2283-7 PMID: 329277
  9. Identification of protein X of Escherichia coli as the recA+/tif+ gene product.
    Mol Gen Genet. 1977 Sep 21;155(1):77-85 PMID: 337120
  10. Protein X is the product of the recA gene of Escherichia coli.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5275-9 PMID: 341151
  11. Identification of the recA (tif) gene product of Escherichia coli.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5280-4 PMID: 341152
  12. Fragmentation of deoxyribonucleic acid by bleomycin.
    Mol Pharmacol. 1971 Nov;7(6):645-52 PMID: 4112751
  13. The recBC deoxyribonuclease of Escherichia coli K-12. Substrate specificity and reaction intermediates.
    J Biol Chem. 1973 Jul 25;248(14):4874-84 PMID: 4268693
  14. The recBC deoxyribonuclease of Escherichia coli: isolation and characterization of the subunit proteins and reconstitution of the enzyme.
    Proc Natl Acad Sci U S A. 1974 Dec;71(12):4816-20 PMID: 4280072
  15. The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes.
    J Biol Chem. 1971 Nov;246(21):6543-55 PMID: 4332130
  16. An adenosine triphosphate-dependent deoxyribonuclease from Hemophilus influenzae Rd. 3. Substrate specificity.
    J Biol Chem. 1972 May 10;247(9):2859-65 PMID: 4337105
  17. Prophage induction by high temperature in thermosensitive dna mutants lysogenic for bacteriophage lambda.
    J Virol. 1973 Jun;11(6):879-85 PMID: 4576518
  18. Thermal enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli B-r: evidence that ultraviolet mutagenesis depends upon an inducible function.
    Proc Natl Acad Sci U S A. 1974 May;71(5):1930-4 PMID: 4600265
  19. Mode of action of phleomycin on Bacillus subtilis.
    J Bacteriol. 1972 Aug;111(2):586-92 PMID: 4626504
  20. Recombination deficient mutants of Escherichia coli K12 that map between thy A and argA.
    Genetics. 1968 Sep;60(1):19-30 PMID: 4884588
  21. Behavior of lambda bacteriophage in a recombination deficienct strain of Escherichia coli.
    J Virol. 1967 Apr;1(2):283-93 PMID: 4918235
  22. Induction of prophage lambda in a mutant of E. coli K12 defective in initiation of DNA replication at high temperature.
    Mol Gen Genet. 1971;110(4):299-306 PMID: 4930082
  23. On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo.
    J Antibiot (Tokyo). 1969 Sep;22(9):446-8 PMID: 4982665
  24. Interaction of streptonigrin with DNA in vitro.
    Biochim Biophys Acta. 1966 Sep;123(3):648-51 PMID: 5339445
  25. The molecular mechanism of virus induction. I. A procedure for the biochemical assay of prophage induction.
    Mol Gen Genet. 1976 Oct 18;148(2):131-8 PMID: 790152
  26. Identification and radiochemical purification of the recA protein of Escherichia coli K-12.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3979-83 PMID: 792880
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.4.1657
Published
1978-04-00
Pages
1657-61
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392397
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.4.1657 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2