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PMID: 6273810 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The effect of sequence specific DNA methylation on restriction endonuclease cleavage.

Nucleic acids research ·Vol. 9 ·No. 22 ·1981-11-25 ·Pages 5859-66

McClelland M

Abstract

Sequence specific DNA methylation sometimes results in the protection of some or all of a restriction endonucleases' cleavage sites. This is usually, but not always, the result of methylation of one or both strands of DNA at the site characteristic of the corresponding "cognate" modification methylase. The known effects of sequence specific methylation on restriction endonucleases are compiled.

MeSH Terms
Base Sequence DNA DNA (Cytosine-5-)-Methyltransferases/metabolism DNA Restriction Enzymes/metabolism Methyltransferases/metabolism Substrate Specificity
Chemicals
DNA Methyltransferases DNA (Cytosine-5-)-Methyltransferases DNA Restriction Enzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
McClelland M
References (46)
46 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/9.22.5859
Published
1981-11-25
Pages
5859-66
Language
English
Region
England
NLM ID
0411011
PMCID
PMC327569
Subset
IM
Grants
NCRR NIH HHS · RF 10-21-RR093-009 · United States
External Links
PubMed source DOI: 10.1093/nar/9.22.5859 PMC Full Text View journal details
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