Home LiteratureArticle Details
PMID: 6197628 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene.

Molecular and cellular biology ·Vol. 3 ·No. 12 ·1983-12-00 ·Pages 2298-301

Parada LF, Weinberg RA

Abstract

Oncogenes have previously been reported in the DNAs of mouse fibroblast lines which had become transformed after in vitro exposure to the carcinogen 3-methylcholanthrene. These oncogenes are now shown to be versions of the cellular Kirsten ras gene and are therefore homologous to oncogenes detected in a variety of human tumor DNAs.

MeSH Terms
Animals Carcinogens Cell Transformation, Neoplastic Cells, Cultured DNA, Neoplasm/isolation & purification DNA, Viral/isolation & purification Genes, Viral Kirsten murine sarcoma virus/genetics Methylcholanthrene/toxicity Mice Mice, Inbred BALB C Mice, Inbred C3H Poly A/genetics,isolation & purification RNA/genetics,isolation & purification RNA, Messenger Sarcoma Viruses, Murine/genetics Transfection Viral Proteins/isolation & purification
Chemicals
Carcinogens DNA, Neoplasm DNA, Viral RNA, Messenger Viral Proteins Poly A Methylcholanthrene RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Parada L F
Weinberg R A
References (24)
24 references, click to expand
  1. Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division.
    Cancer Res. 1973 Dec;33(12):3239-49 PMID: 4796800
  2. Partial transcription of murine type C viral genomes in BALB c cell lines.
    J Virol. 1973 Oct;12(4):711-20 PMID: 4359949
  3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  4. Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5714-8 PMID: 230490
  5. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3855-9 PMID: 6933441
  6. Unique transforming gene in carcinogen-transformed mouse cells.
    Nature. 1981 Feb 12;289(5798):607-9 PMID: 6258087
  7. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
    Nature. 1981 Aug 6;292(5823):506-11 PMID: 6265801
  8. Three different human tumor cell lines contain different oncogenes.
    Cell. 1981 Aug;25(2):355-61 PMID: 6269741
  9. Proposal for naming host cell-derived inserts in retrovirus genomes.
    J Virol. 1981 Dec;40(3):953-7 PMID: 7321107
  10. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.
    Nature. 1982 Jun 10;297(5866):474-8 PMID: 6283357
  11. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
    Nature. 1982 Jul 22;298(5872):343-7 PMID: 6283384
  12. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
    Proc Natl Acad Sci U S A. 1982 Jun;79(11):3637-40 PMID: 6285355
  13. Isolation of a transforming sequence from a human bladder carcinoma cell line.
    Cell. 1982 May;29(1):161-9 PMID: 6286138
  14. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family.
    J Virol. 1982 Jul;43(1):294-304 PMID: 6287003
  15. Mechanism of activation of a human oncogene.
    Nature. 1982 Nov 11;300(5888):143-9 PMID: 6290897
  16. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.
    Nature. 1982 Nov 11;300(5888):149-52 PMID: 7133135
  17. Oncogenes in solid human tumours.
    Nature. 1982 Dec 9;300(5892):539-42 PMID: 7144906
  18. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.
    Nature. 1982 Dec 23;300(5894):762-5 PMID: 7177195
  19. Characterization of a human colon/lung carcinoma oncogene.
    Nature. 1983 Mar 3;302(5903):79-81 PMID: 6298638
  20. Three human transforming genes are related to the viral ras oncogenes.
    Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6 PMID: 6572964
  21. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene.
    Nature. 1983 May 5-11;303(5912):72-4 PMID: 6843661
  22. Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene.
    Science. 1983 May 27;220(4600):955-6 PMID: 6302839
  23. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.
    Nature. 1983 Jun 9-15;303(5917):497-501 PMID: 6304530
  24. The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors.
    Cell. 1983 Jul;33(3):749-57 PMID: 6683594
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.3.12.2298-2301.1983
Published
1983-12-00
Pages
2298-301
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC370101
Subset
IM
Grants
NCI NIH HHS · CA14051 · United States
NCI NIH HHS · CA26717 · United States
External Links
PubMed source DOI: 10.1128/mcb.3.12.2298-2301.1983 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2