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PMID: 6182563 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Transcriptional control of the murine albumin/alpha-fetoprotein locus during development.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 17 ·1982-09-00 ·Pages 5254-7

Tilghman SM, Belayew A

Abstract

The ontogeny of expression of the alpha-fetoprotein (AFP) and albumin genes was examined in livers from late prenatal to 1-month-postpartum C3H/He mice. A parallel accumulation of both AFP and albumin mRNAs before birth, followed by a selective nonreciprocal decrease in AFP mRNA after birth, was observed. The decrease in AFP mRNA was the result of a decrease in transcription of the AFP gene, as measured by an in vitro nuclear transcription assay. We suggest a model for hepatic expression of the AFP and albumin gene cluster in which transcription of the two genes is activated simultaneously during differentiation and each gene is thereafter modulated independently in committed cells.

MeSH Terms
Aging Animals Female Gestational Age Liver/embryology,growth & development Mice Mice, Inbred C3H Nucleic Acid Hybridization Pregnancy RNA, Messenger/genetics Serum Albumin/genetics Transcription, Genetic alpha-Fetoproteins/genetics
Chemicals
RNA, Messenger Serum Albumin alpha-Fetoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tilghman S M
Belayew A
References (34)
34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.17.5254
Published
1982-09-00
Pages
5254-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346874
Subset
IM
Grants
NCI NIH HHS · CA-06927 · United States
NCI NIH HHS · CA-28050 · United States
NCRR NIH HHS · RR-05539 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.17.5254 PMC Full Text View journal details
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