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PMID: 4215083 Published · ppublish English Journal Article

Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 9 ·1974-09-00 ·Pages 3659-63

Honjo T, Packman S, Swan D, Nau M, Leder P

Abstract

Hybridization kinetic analyses with synthetic DNA indicate that there are only two to three copies of the kappa constant region gene per haploid genome. This result lends weight to the argument that the immunoglobulin light chain is encoded by more than one continuous gene sequence.

MeSH Terms
Animals Base Sequence Cell Line Centrifugation, Density Gradient DNA, Neoplasm/analysis Electrophoresis, Polyacrylamide Gel Genes Genetic Code Haploidy Immunoglobulin Fragments/biosynthesis Immunoglobulin kappa-Chains/biosynthesis Kinetics Mice Neoplasms, Experimental/analysis Nucleic Acid Hybridization Plasmacytoma RNA, Messenger/metabolism Transcription, Genetic Tritium
Chemicals
DNA, Neoplasm Immunoglobulin Fragments Immunoglobulin kappa-Chains RNA, Messenger Tritium
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Honjo T
Packman S
Swan D
Nau M
Leder P
References (53)
53 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.9.3659
Published
1974-09-00
Pages
3659-63
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433835
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.9.3659 PMC Full Text View journal details
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