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PMID: 6167988 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 6 ·1981-06-00 ·Pages 3521-5

Jagodzinski LL, Sargent TD, Yang M, Glackin C, Bonner J

Abstract

We have determined the sequences of the recombinant DNA inserts of three bacterial plasmid cDNA clones containing most of the rat alpha a-fetoprotein mRNA. The resultant nucleotide sequence of alpha-fetoprotein was exhaustively compared to the nucleotide sequence of the mRNA encoding rat serum albumin. These two mRNAs have extensive homology (50%) throughout and the same intron locations. The amino acid sequence of rat alpha-fetoprotein has been deduced from the nucleotide sequence, and its comparison to rat serum albumin's amino acid sequence reveals a 34% homology. The regularly spaced positions of the cysteines found in serum albumin are conserved in rat alpha-fetoprotein, indicating that these two proteins may have a similar secondary folding structure. These homologies indicate that alpha-fetoprotein and serum albumin were derived by duplication of a common ancestral gene and constitute a gene family.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Cloning, Molecular RNA, Messenger/genetics Rats Serum Albumin/genetics alpha-Fetoproteins/genetics
Chemicals
RNA, Messenger Serum Albumin alpha-Fetoproteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jagodzinski L L
Sargent T D
Yang M
Glackin C
Bonner J
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.6.3521
Published
1981-06-00
Pages
3521-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319601
Subset
IM
Grants
NIGMS NIH HHS · 5 T32 GM 07616 · United States
NIGMS NIH HHS · GM 13762 · United States
Databases
GENBANK
J00695
External Links
PubMed source DOI: 10.1073/pnas.78.6.3521 PMC Full Text View journal details
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