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PMID: 6164927 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin.

Nature ·Vol. 291 ·No. 5812 ·1981-05-21 ·Pages 201-5

Law SW, Dugaiczyk A

Abstract

The entire DNA complementary to murine alpha-fetoprotein mRNA has been cloned in the plasmid vector pBR322 and its complete nucleotide sequence determined. The deduced amino acid sequence identifies a hydrophobic prepeptide of 19 amino acids and the complete primary structure of alpha-fetoprotein. Its structure reveals extensive homology to serum albumin and suggests that there are 15 disulphide bridges in the alpha-fetoprotein molecule, all at the same positions as those found in albumin. The AFP molecule can be organized into a three-domain structure almost identical to that of serum albumin, suggesting a common ancestral origin of the two proteins.

MeSH Terms

Amino Acid Sequence Animals Base Sequence DNA, Recombinant Escherichia coli/genetics Mice Plasmids Protein Biosynthesis RNA, Messenger/genetics Serum Albumin Transcription, Genetic alpha-Fetoproteins/genetics

Chemicals

DNA, Recombinant RNA, Messenger Serum Albumin alpha-Fetoproteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Law S W

Dugaiczyk A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/291201a0

Published

1981-05-21

Pages

201-5

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J00348, M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393, M16394, M16395

External Links

PubMed source DOI: 10.1038/291201a0 View journal details

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Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin.

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