Home LiteratureArticle Details
PMID: 6098810 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene.

Molecular and cellular biology ·Vol. 4 ·No. 12 ·1984-12-00 ·Pages 2565-72

Hawley RG, Shulman MJ, Hozumi N

Abstract

Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns. One IAP element generated 6-base-pair direct repeats upon insertion. In contrast, the other IAP element was not flanked by direct repeats and was missing a single nucleotide from its 3' terminus. Sequence analysis of the latter IAP element demonstrated that its long terminal repeats were not identical. Nevertheless, the long terminal repeats were organized like proviral long terminal repeats, and this IAP element did contain two regions that were analogous to retroviral priming sites for RNA-directed DNA synthesis. The region that corresponded to a retroviral tRNA primer binding site was complementary to the 3' ends of all mammalian phenylalanine tRNAs. These findings are discussed in the context of the presumed mode of transposition of IAP elements involving the reverse transcription of IAP RNA.

MeSH Terms
Animals Base Sequence DNA Restriction Enzymes/metabolism DNA Transposable Elements Immunoglobulin Light Chains/genetics Immunoglobulin kappa-Chains/genetics Mice Mutation Oncogenes Repetitive Sequences, Nucleic Acid Retroviridae/genetics Transcription, Genetic
Chemicals
DNA Transposable Elements Immunoglobulin Light Chains Immunoglobulin kappa-Chains DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hawley R G
Shulman M J
Hozumi N
References (51)
51 references, click to expand
  1. Insertion of retrovirus into the first intron of alpha 1(I) collagen gene to embryonic lethal mutation in mice.
    Proc Natl Acad Sci U S A. 1984 Mar;81(5):1504-8 PMID: 6324198
  2. Transposition of intracisternal A-particle genes in mouse hybridomas.
    J Cell Physiol Suppl. 1984;3:29-38 PMID: 6086685
  3. Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences.
    Mol Cell Biol. 1984 Jul;4(7):1402-10 PMID: 6095069
  4. Intracisternal A-particle genes in Mus musculus: a conserved family of retrovirus-like elements.
    Mol Cell Biol. 1981 Mar;1(3):216-27 PMID: 6821514
  5. Chromosome organization and genic expression.
    Cold Spring Harb Symp Quant Biol. 1951;16:13-47 PMID: 14942727
  6. Distribution of intracisternal A-particles in a variety of normal and neoplastic mouse tissues.
    Int J Cancer. 1971 Jan 15;7(1):167-75 PMID: 4322935
  7. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.
    Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 PMID: 4504350
  8. Intracisternal A particles in ova and preimplantation stages of the mouse.
    Nat New Biol. 1973 May 16;243(124):91-3 PMID: 4512964
  9. Virus particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Sep;51(3):1041-50 PMID: 4795510
  10. Expression of A- and C-type particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Dec;51(6):1971-5 PMID: 4358153
  11. Studies on the relationship between deoxyribonucleic acid polymerase activity and intracisternal A-type particles in mouse myeloma.
    Biochemistry. 1974 Mar 12;13(6):1087-94 PMID: 4360775
  12. Characterization of an endogenous RNA-dependent DNA polymerase associated with murine intracisternal A particles.
    J Virol. 1974 Mar;13(3):712-20 PMID: 4132671
  13. Expression of genes for intracisternal A-particle antigen in somatic cell hybrids.
    J Natl Cancer Inst. 1974 Apr;52(4):1211-7 PMID: 4363705
  14. 3' non-coding region sequences in eukaryotic messenger RNA.
    Nature. 1976 Sep 16;263(5574):211-4 PMID: 822353
  15. RNA sequences specifically associated with mouse intracisternal A particles.
    Cell. 1977 May;11(1):83-94 PMID: 68836
  16. Sequences associated with intracisternal A particles are reiterated in the mouse genome.
    Cell. 1977 Dec;12(4):963-72 PMID: 597866
  17. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  18. RNA associated with murine intracisternal type A particles codes for the main particle protein.
    J Virol. 1978 Jul;27(1):118-26 PMID: 691107
  19. The isolation of structural genes from libraries of eucaryotic DNA.
    Cell. 1978 Oct;15(2):687-701 PMID: 719759
  20. The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells.
    Cell. 1978 Dec;15(4):1495-509 PMID: 103631
  21. Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogenity at the mRNA 5' end.
    Cell. 1979 Oct;18(2):569-80 PMID: 227610
  22. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  23. Molecular consequences of deletion formation mediated by the transposon Tn9.
    Nature. 1980 May 1;285(5759):38-41 PMID: 6246435
  24. 3'-end labeling of DNA with [alpha-32P]cordycepin-5'-triphosphate.
    Gene. 1980 Jul;10(2):177-83 PMID: 6248422
  25. Sequence organization of cloned intracisternal A particle genes.
    Cell. 1980 Sep;21(2):465-73 PMID: 6250723
  26. Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3571-5 PMID: 6251469
  27. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 PMID: 6159641
  28. The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.
    J Biol Chem. 1981 May 25;256(10):5116-20 PMID: 6262318
  29. Molecular cloning of an immunoglobulin kappa constant gene from NZB mouse.
    Gene. 1981 Mar;13(2):163-172 PMID: 6453743
  30. Terminally redundant sequences in cellular intracisternal A-particle genes.
    J Virol. 1981 May;38(2):680-7 PMID: 7241664
  31. Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus.
    Cell. 1981 Jul;25(1):23-36 PMID: 6268304
  32. Transcriptional control regions: nucleotide sequence requirements for initiation by RNA polymerase II and III.
    Curr Top Microbiol Immunol. 1981;93:25-46 PMID: 7026181
  33. RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.
    Proc Natl Acad Sci U S A. 1981 Nov;78(11):7019-23 PMID: 6171827
  34. Structure, variation and synthesis of retrovirus long terminal repeat.
    Cell. 1981 Nov;27(1 Pt 2):1-3 PMID: 7326747
  35. Compilation of tRNA sequences.
    Nucleic Acids Res. 1982 Jan 22;10(2):r1-55 PMID: 7063409
  36. A catalogue of splice junction sequences.
    Nucleic Acids Res. 1982 Jan 22;10(2):459-72 PMID: 7063411
  37. Transposable elements in prokaryotes.
    Annu Rev Genet. 1981;15:341-404 PMID: 6279020
  38. Intracisternal A-particle genes: structure of adjacent genes and mapping of the boundaries of the transcriptional unit.
    J Virol. 1982 Apr;42(1):123-30 PMID: 6283134
  39. Differing populations of intracisternal A-particle genes in myeloma tumors and mouse subspecies.
    J Virol. 1982 May;42(2):411-21 PMID: 6283165
  40. Functional significance and evolutionary development of the 5'-terminal regions of immunoglobulin variable-region genes.
    Cell. 1982 Jun;29(2):681-9 PMID: 6288267
  41. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7425-9 PMID: 6296832
  42. Retrovirus-like particles containing RNA homologous to the transposable element copia in Drosophila melanogaster.
    Nature. 1983 Mar 10;302(5904):119-24 PMID: 6186922
  43. Intracisternal A-particle genes as movable elements in the mouse genome.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1992-6 PMID: 6300886
  44. RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.
    Proc Natl Acad Sci U S A. 1983 May;80(9):2432-6 PMID: 6189122
  45. Close relationship between the long terminal repeats of avian leukosis-sarcoma virus and copia-like movable genetic elements of Drosophila.
    Proc Natl Acad Sci U S A. 1983 Jun;80(11):3193-7 PMID: 6304696
  46. New M13 vectors for cloning.
    Methods Enzymol. 1983;101:20-78 PMID: 6310323
  47. The origin of extrachromosomal circular copia elements.
    Cell. 1983 Sep;34(2):415-9 PMID: 6616617
  48. Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.
    Proc Natl Acad Sci U S A. 1983 Dec;80(23):7118-22 PMID: 6316344
  49. Amplification of a specific set of intracisternal A-particle genes in a mouse plasmacytoma.
    J Virol. 1984 Jan;49(1):171-7 PMID: 6690709
  50. Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.
    Nature. 1983 Dec 22-1984 Jan 4;306(5945):797-9 PMID: 6656883
  51. Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.
    Nucleic Acids Res. 1984 Feb 24;12(4):1767-78 PMID: 6322120
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.12.2565-2572.1984
Published
1984-12-00
Pages
2565-72
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369258
Subset
IM
Databases
GENBANK
J00561, J00569, M12418, M12419, M12420
External Links
PubMed source DOI: 10.1128/mcb.4.12.2565-2572.1984 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2