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PMID: 6316344 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 23 ·1983-12-00 ·Pages 7118-22

Canaani E, Dreazen O, Klar A, Rechavi G, Ram D, Cohen JB, Givol D

Abstract

The activation of the cellular oncogene c-mos in mouse plasmacytoma XRPC24 was found to result from the insertion of a 4.7-kilobase-pair cellular DNA element, within the c-mos coding region. The element terminates on both sides with a direct repeat of around 335 nucleotides. The repeat as well as internal sequences of the element show strong homology to endogenous intracisternal A-particle (IAP) genes. The IAP genome integrated within c-mos in a head-to-head (5' to 5') configuration. This juxtapositioned the IAP 5' long terminal repeat next to the bulk of the oncogene's coding region and shifted c-mos 5' coding and flanking sequences to a position further upstream. The significance of several aspects of this activation and transposition event is discussed.

MeSH Terms
Animals Base Sequence Cell Line Cloning, Molecular DNA Restriction Enzymes DNA Transposable Elements DNA, Neoplasm/genetics Mice Mice, Inbred BALB C Nucleic Acid Hybridization Oncogenes Plasmacytoma/genetics
Chemicals
DNA Transposable Elements DNA, Neoplasm DNA Restriction Enzymes
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Canaani E
Dreazen O
Klar A
Rechavi G
Ram D
Cohen J B
Givol D
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.23.7118
Published
1983-12-00
Pages
7118-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC390004
Subset
IM
Databases
GENBANK
K00983, K00984
External Links
PubMed source DOI: 10.1073/pnas.80.23.7118 PMC Full Text View journal details
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