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PMID: 6304535 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences.

Nature ·Vol. 303 ·No. 5919 ·1983-00-00 ·Pages 674-9

Nordheim A, Rich A

Abstract

Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.

MeSH Terms

Animals Antibodies Antigen-Antibody Complex Base Sequence Cell Line Chlorocebus aethiops DNA, Superhelical/genetics DNA, Viral/genetics Genes, Regulator Genes, Viral Kidney Retroviridae/genetics Simian virus 40/genetics Species Specificity Transcription, Genetic

Chemicals

Antibodies Antigen-Antibody Complex DNA, Superhelical DNA, Viral

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nordheim A

Rich A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/303674a0

Published

1983-00-00

Pages

674-9

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/303674a0 View journal details

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Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences.

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