Home LiteratureArticle Details
PMID: 6095203 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A retroviral provirus closely associated with the Ren-2 gene of DBA/2 mice.

Nucleic acids research ·Vol. 12 ·No. 22 ·1984-11-26 ·Pages 8579-93

Burt DW, Reith AD, Brammar WJ

Abstract

We have determined the entire nucleotide sequence of an intra-cisternal A particle (IAP) genome, associated with the Ren-2 gene of DBA/2 mice. This genome (MIARN) displays features common to other IAP retroviral-like genomes. Long terminal repeats (LTRs) are approximately 430 base pairs (bp) in length and show typical retroviral U3-R-U5 organisation, though the R-region, at 120 bp, is much larger than the average IAP. This difference probably arose by the amplification of a pyrimidine-rich sequence, by a slippage-mispairing mechanism. Flanking the 5' LTR is a sequence complementary to a phenylalanine tRNA, strongly conserved in all rodent IAP genomes and probably required to prime the initiation of (-) strand synthesis. Flanking the 3' LTR, is a purine-rich sequence probably required for (+) strand synthesis. The tRNA binding site (TBS) is flanked by six tandem copies of a sequence homologous to the TBS. The relationship of the MIARN element to other IAP genomes and the significance of its association with the highly expressed Ren-2 is discussed.

MeSH Terms
Animals Base Sequence Computers DNA Restriction Enzymes Genes, Viral Mice Mice, Inbred DBA Molecular Sequence Data Oncogenes Plasmids Retroviridae/genetics
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Burt D W
Reith A D
Brammar W J
References (63)
63 references, click to expand
  1. The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus.
    Nature. 1983 Aug 25-31;304(5928):749-52 PMID: 6310405
  2. The diagonal-traverse homology search algorithm for locating similarities between two sequences.
    Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):751-66 PMID: 6320108
  3. Conserved sequence related to the 3'-terminal region of retrovirus RNA'S In normal cellular DNAs.
    J Virol. 1980 Jun;34(3):684-92 PMID: 6770102
  4. Molecular cloning of two distinct renin genes from the DBA/2 mouse.
    EMBO J. 1982;1(11):1461-6 PMID: 6327270
  5. Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.
    Proc Natl Acad Sci U S A. 1978 Nov;75(11):5623-6 PMID: 281712
  6. Electron microscope study of a cell-free induced leukemia of the mouse: a preliminary report.
    J Biophys Biochem Cytol. 1958 Mar 25;4(2):151-6 PMID: 13525427
  7. The extraction of intracisternal A-particles from a mouse plasma-cell tumor.
    Cancer Res. 1968 Oct;28(10):2137-48 PMID: 5696942
  8. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.
    Nature. 1981 Oct 1;293(5831):370-4 PMID: 6268990
  9. Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3' consensus sequence AAUAAA.
    Nature. 1983 Oct 13-19;305(5935):600-5 PMID: 6194440
  10. Long terminal repeat of murine retroviral DNAs: sequence analysis, host-proviral junctions, and preintegration site.
    J Virol. 1982 Feb;41(2):542-56 PMID: 6281466
  11. Genetic control of renin activity in the submaxillary gland of the mouse.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9 PMID: 15253
  12. Two distinct endogenous type C viruses isolated from the asian rodent Mus cervicolor: conservation of virogene sequences in related rodent species.
    J Virol. 1977 Mar;21(3):849-62 PMID: 66330
  13. Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.
    Nature. 1983 Jul 28-Aug 3;304(5924):315-20 PMID: 6308457
  14. Sequences homologous to retrovirus-like genes of the mouse are present in multiple copies in the Syrian hamster genome.
    Nucleic Acids Res. 1981 Nov 25;9(22):5917-30 PMID: 7198224
  15. Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.
    Nucleic Acids Res. 1984 Feb 24;12(4):1767-78 PMID: 6322120
  16. Identification of ecotropic proviral sequences in inbred mouse strains with a cloned subgenomic DNA fragment.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5779-83 PMID: 6255465
  17. Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element.
    Nature. 1982 Dec 16;300(5893):607-11 PMID: 6292737
  18. Intracisternal A particles in ova and preimplantation stages of the mouse.
    Nat New Biol. 1973 May 16;243(124):91-3 PMID: 4512964
  19. Intracisternal A-particle genes: identification in the genome of Mus musculus and comparison of multiple isolates from a mouse gene library.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3571-5 PMID: 6251469
  20. Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.
    EMBO J. 1983;2(8):1423-9 PMID: 10872340
  21. Expression of A- and C-type particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Dec;51(6):1971-5 PMID: 4358153
  22. Estimation of evolutionary distances between homologous nucleotide sequences.
    Proc Natl Acad Sci U S A. 1981 Jan;78(1):454-8 PMID: 6165991
  23. Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene.
    Nature. 1983 Apr 7;302(5908):547-8 PMID: 6835385
  24. Association between a transposed alpha-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome.
    Nature. 1982 Feb 4;295(5848):426-8 PMID: 7057906
  25. DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.
    Cell. 1983 Jun;33(2):489-99 PMID: 6190571
  26. Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs.
    Cell. 1983 Jun;33(2):379-87 PMID: 6305507
  27. Molecular cloning of retrovirus-like genes present in multiple copies in the Syrian hamster genome.
    Nucleic Acids Res. 1982 Oct 11;10(19):5733-46 PMID: 6292848
  28. Long terminal repeat sequences of intracisternal A particle genes in the Syrian hamster genome: identification of tRNAPhe as a putative primer tRNA.
    Nucleic Acids Res. 1983 Oct 25;11(20):7169-79 PMID: 6314280
  29. Sequence organization of cloned intracisternal A particle genes.
    Cell. 1980 Sep;21(2):465-73 PMID: 6250723
  30. Nucleotide sequence of bacteriophage lambda DNA.
    J Mol Biol. 1982 Dec 25;162(4):729-73 PMID: 6221115
  31. Sequences associated with intracisternal A particles are reiterated in the mouse genome.
    Cell. 1977 Dec;12(4):963-72 PMID: 597866
  32. A catalogue of splice junction sequences.
    Nucleic Acids Res. 1982 Jan 22;10(2):459-72 PMID: 7063411
  33. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.
    Nature. 1981 Apr 9;290(5806):475-80 PMID: 6261142
  34. Some ultrastructural characteristics of a series of primary and transplanted plasma-cell tumors of the mouse.
    J Natl Cancer Inst. 1961 May;26:1221-67 PMID: 13719477
  35. Molecular cloning and long terminal repeat sequences of intracisternal A-particle genes in Mus caroli.
    J Virol. 1984 May;50(2):352-8 PMID: 6708171
  36. Proviral deletions and oncogene base-substitutions in insertionally mutagenized c-myc alleles may contribute to the progression of avian bursal tumors.
    Proc Natl Acad Sci U S A. 1984 Feb;81(3):843-7 PMID: 6322173
  37. The primary structure of rabbit, calf and bovine liver tRNAPhe.
    Biochim Biophys Acta. 1978 Jan 26;517(1):133-49 PMID: 414781
  38. On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3418-22 PMID: 6267589
  39. Differing populations of intracisternal A-particle genes in myeloma tumors and mouse subspecies.
    J Virol. 1982 May;42(2):411-21 PMID: 6283165
  40. Conserved region of mammalian retrovirus RNA.
    J Virol. 1979 Dec;32(3):925-33 PMID: 229272
  41. Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday.
    Cold Spring Harb Symp Quant Biol. 1966;31:77-84 PMID: 5237214
  42. Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.
    Proc Natl Acad Sci U S A. 1984 May;81(10):3029-33 PMID: 6328488
  43. Distribution of intracisternal A-particles in a variety of normal and neoplastic mouse tissues.
    Int J Cancer. 1971 Jan 15;7(1):167-75 PMID: 4322935
  44. Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes.
    J Mol Biol. 1981 Aug 25;150(4):441-66 PMID: 6276556
  45. Structure, variation and synthesis of retrovirus long terminal repeat.
    Cell. 1981 Nov;27(1 Pt 2):1-3 PMID: 7326747
  46. Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death.
    Cell. 1983 Jan;32(1):209-16 PMID: 6825169
  47. Transcriptional termination sites in the b2 region of bacteriophage lambda that are unresponsive to antitermination.
    Mol Gen Genet. 1982;185(3):462-7 PMID: 6285144
  48. Terminally redundant sequences in cellular intracisternal A-particle genes.
    J Virol. 1981 May;38(2):680-7 PMID: 7241664
  49. Murine intracisternal A type particles fail to separate from the membrane of the endoplasmic reticulum.
    J Virol. 1974 Nov;14(5):1304-6 PMID: 4431082
  50. Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7425-9 PMID: 6296832
  51. Virus particles in early mouse embryos.
    J Natl Cancer Inst. 1973 Sep;51(3):1041-50 PMID: 4795510
  52. Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.
    Proc Natl Acad Sci U S A. 1983 Dec;80(23):7118-22 PMID: 6316344
  53. The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication.
    EMBO J. 1982;1(11):1417-21 PMID: 6327268
  54. Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas.
    Nature. 1983 Dec 22-1984 Jan 4;306(5945):797-9 PMID: 6656883
  55. Organization and expression of eucaryotic split genes coding for proteins.
    Annu Rev Biochem. 1981;50:349-83 PMID: 6791577
  56. Intracisternal A-particle genes as movable elements in the mouse genome.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1992-6 PMID: 6300886
  57. Sequence studies on tRNAPhe from placenta: comparison with known sequences of tRNAPhe from other normal mammalian tissues.
    Biochem Biophys Res Commun. 1975 Oct 27;66(4):1097-105 PMID: 1191278
  58. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus.
    J Virol. 1982 Jul;43(1):26-36 PMID: 6287001
  59. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
    J Mol Biol. 1980 Oct 25;143(2):161-78 PMID: 6260957
  60. Evolution of aspartyl proteases by gene duplication: the mouse renin gene is organized in two homologous clusters of four exons.
    EMBO J. 1984 Mar;3(3):557-62 PMID: 6370686
  61. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland.
    Cell. 1982 Aug;30(1):205-13 PMID: 6751556
  62. Characteristics of and relationship between C particles and intracisternal A particles in cloned cell strains.
    J Virol. 1968 Mar;2(3):238-47 PMID: 4316022
  63. Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice.
    EMBO J. 1983;2(5):675-8 PMID: 6357783
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.22.8579
Published
1984-11-26
Pages
8579-93
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320400
Subset
IM
Databases
GENBANK
X01172
External Links
PubMed source DOI: 10.1093/nar/12.22.8579 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2