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PMID: 281712 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 11 ·1978-11-00 ·Pages 5623-6

Wilson CM, Erdös EG, Wilson JD, Taylor BA

Abstract

Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species.

MeSH Terms

Animals Chromosomes/metabolism Crosses, Genetic Genes, Regulator Mice Mice, Inbred Strains Recombination, Genetic Renin/genetics,metabolism Submandibular Gland/enzymology

Chemicals

Renin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Wilson C M

Erdös E G

Wilson J D

Taylor B A

References (26)

26 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.11.5623

Published

1978-11-00

Pages

5623-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC393019

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.11.5623 PMC Full Text View journal details

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Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse.

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