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PMID: 196096 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

Journal of virology ·Vol. 23 ·No. 1 ·1977-07-00 ·Pages 106-9

Taylor BA, Bedigian HG, Meier H

Abstract

Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.

MeSH Terms
Animals Cell Line Chromosome Mapping Crossing Over, Genetic Genes Genetic Linkage Genotype Glucosephosphate Dehydrogenase/biosynthesis Isoenzymes/biosynthesis Leukemia Virus, Murine/growth & development Mice Mice, Inbred Strains Phosphogluconate Dehydrogenase/biosynthesis Polymorphism, Genetic Recombination, Genetic
Chemicals
Isoenzymes Phosphogluconate Dehydrogenase Glucosephosphate Dehydrogenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taylor B A
Bedigian H G
Meier H
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24 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.23.1.106-109.1977
Published
1977-07-00
Pages
106-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC515805
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.23.1.106-109.1977 PMC Full Text View journal details
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