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PMID: 6087351 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 15 ·1984-08-00 ·Pages 4874-8

Zabel BU, Fournier RE, Lalley PA, Naylor SL, Sakaguchi AY

Abstract

Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11----qter) and located c-erb-B on human chromosome 7 (7pter----q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.

MeSH Terms
Alpharetrovirus/genetics Animals Avian Leukosis Virus/genetics Chromosome Mapping Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X Genes, Viral Genetic Linkage Hematopoiesis Humans Mice Oncogenes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zabel B U
Fournier R E
Lalley P A
Naylor S L
Sakaguchi A Y
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.15.4874
Published
1984-08-00
Pages
4874-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391594
Subset
IM
Grants
NCI NIH HHS · CA16056 · United States
NIGMS NIH HHS · GM20454 · United States
NIGMS NIH HHS · GM26449 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.15.4874 PMC Full Text View journal details
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